Estrogen receptor coregulators in brain meet the specificity of estrogen action: a possible roadmap for therapeutics

Recently our laboratory has identified many estrogen receptor (ER)α and ERβ coregulators in the brain. This has raised many important issues, more strikingly, regarding the motif specificity, as most of the coregulators reported earlier were from other tissues and related to diseases. It has also aided to the sophistication of transcriptional regulation of genes. Here we have discussed implications of ER coregulators and explored whether they could determine the specificity needed for regulation of estrogen action. Tissue and receptor specificity of coregulators and their motifs might be useful in designing peptide specific agonist and/or antagonist which can regulate specific estrogen action and be used in therapeutics. Keywords : Coregulators; Estrogen receptor; Estrogen action; Specificity; Brain; Peptide agonist/antagonist