肌萎缩侧索硬化症的干细胞治疗

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2015-01-01 DOI:10.1186/s13619-015-0026-7

Zhijuan Mao , Suming Zhang , Hong Chen

{"title":"肌萎缩侧索硬化症的干细胞治疗","authors":"Zhijuan Mao , Suming Zhang , Hong Chen","doi":"10.1186/s13619-015-0026-7","DOIUrl":null,"url":null,"abstract":"<div><p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has only limited clinical benefits. Stem-cell-based therapy has been intensively and extensively studied as a potential novel treatment strategy for ALS and has been shown to be effective, at least to some extent. In this article, we will review the current state of research on the use of stem cell therapy in the treatment of ALS and discuss the most promising stem cells for the treatment of ALS.</p></div>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"4 1","pages":"Article 4:11"},"PeriodicalIF":4.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13619-015-0026-7","citationCount":"12","resultStr":"{\"title\":\"Stem cell therapy for amyotrophic lateral sclerosis\",\"authors\":\"Zhijuan Mao , Suming Zhang , Hong Chen\",\"doi\":\"10.1186/s13619-015-0026-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has only limited clinical benefits. Stem-cell-based therapy has been intensively and extensively studied as a potential novel treatment strategy for ALS and has been shown to be effective, at least to some extent. In this article, we will review the current state of research on the use of stem cell therapy in the treatment of ALS and discuss the most promising stem cells for the treatment of ALS.</p></div>\",\"PeriodicalId\":9811,\"journal\":{\"name\":\"Cell Regeneration\",\"volume\":\"4 1\",\"pages\":\"Article 4:11\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s13619-015-0026-7\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Regeneration\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2045976917300147\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL & TISSUE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Regeneration","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2045976917300147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}

引用次数: 12

摘要

肌萎缩侧索硬化症(ALS)是一种致命的神经退行性疾病，其特征是运动神经元的丧失。目前，除了利鲁唑(Riluzole)之外，没有有效的治疗ALS的药物，但它的临床疗效有限。干细胞疗法作为一种潜在的治疗ALS的新策略已经得到了广泛而深入的研究，并且至少在某种程度上已经被证明是有效的。在这篇文章中，我们将回顾干细胞治疗ALS的研究现状，并讨论最有希望治疗ALS的干细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Stem cell therapy for amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has only limited clinical benefits. Stem-cell-based therapy has been intensively and extensively studied as a potential novel treatment strategy for ALS and has been shown to be effective, at least to some extent. In this article, we will review the current state of research on the use of stem cell therapy in the treatment of ALS and discuss the most promising stem cells for the treatment of ALS.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine