静脉平滑肌瘤病不完全切除后心脏延伸的治疗

IF 2.5 Q2 PERIPHERAL VASCULAR DISEASE
M. Doyle, Annette Li, C. Villanueva, S. Peeceeyen, M. Cooper, K. Hanel, G. Fermanis, G. Robertson
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引用次数: 27

摘要

的目标。静脉内平滑肌瘤病合并心脏延伸是一种罕见的良性子宫平滑肌瘤。不完全切除的复发率超过30%。不完全切除后不同的激素治疗已被描述;然而,目前尚无标准的治疗方法。我们回顾了文献中关于CE不完全切除IVL后的医学治疗选择。方法。电子数据库检索所有报告IVL合并CE的研究。然后在这些研究中搜索无法手术或不完全切除的患者报告以及任何进一步的药物治疗。我们在数据库中检索了经CE不完全切除IVL后接受药物治疗的患者,并纳入了他们的结果。结果。所有的研究都是病例报告或病例系列。五篇文献综述证实手术是治愈的唯一治疗方法。不完全切除后使用黄体酮、雌激素调节、促性腺激素释放激素拮抗和芳香酶抑制。目前还没有研究回顾这些治疗的结果。结论。完全手术切除是治疗IVL合并CE的唯一手段,而多种激素治疗在不完全切除后效果不同。芳香酶抑制剂是唯一报道的治疗方法,以防止肿瘤进展或复发的患者未完全切除IVL与CE。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection
Aim. Intravenous leiomyomatosis (IVL) with cardiac extension (CE) is a rare variant of benign uterine leiomyoma. Incomplete resection has a recurrence rate of over 30%. Different hormonal treatments have been described following incomplete resection; however no standard therapy currently exists. We review the literature for medical treatments options following incomplete resection of IVL with CE. Methods. Electronic databases were searched for all studies reporting IVL with CE. These studies were then searched for reports of patients with inoperable or incomplete resection and any further medical treatments. Our database was searched for patients with medical therapy following incomplete resection of IVL with CE and their results were included. Results. All studies were either case reports or case series. Five literature reviews confirm that surgery is the only treatment to achieve cure. The uses of progesterone, estrogen modulation, gonadotropin-releasing hormone antagonism, and aromatase inhibition have been described following incomplete resection. Currently no studies have reviewed the outcomes of these treatments. Conclusions. Complete surgical resection is the only means of cure for IVL with CE, while multiple hormonal therapies have been used with varying results following incomplete resection. Aromatase inhibitors are the only reported treatment to prevent tumor progression or recurrence in patients with incompletely resected IVL with CE.
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来源期刊
International Journal of Vascular Medicine
International Journal of Vascular Medicine PERIPHERAL VASCULAR DISEASE-
CiteScore
3.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
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