MicroRNA在人类疾病中的功能

Medical epigenetics Pub Date : 2013-11-26 DOI:10.1159/000356447

S. Natarajan, Mary A. Smith, Cody J. Wehrkamp, Ashley M. Mohr, J. Mott

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引用次数: 18

摘要

MicroRNAs正在成为研究的热门话题，这是理所当然的。它们作为治疗靶点和人类常见疾病(如癌症和代谢性疾病)的标记物显示出巨大的希望。在这篇综述中，我们讨论了一些关于microRNA在人类疾病中的功能和microRNA的临床意义的基本问题。特别地，以胆管癌和非酒精性脂肪肝为例，讨论了表观遗传学、癌症和代谢性疾病中的microrna。

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MicroRNA Function in Human Diseases

MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding microRNA function in human disease and the clinical significance of microRNAs. Specifically, microRNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.

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Medical epigenetics

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