Ying Liu, Linyuan Feng, Yang Yang, Zhenhua Lin, Wen-zheng Jiang
{"title":"SPOCK1是一种预后相关的生物标志物,与头颈部鳞状细胞癌的免疫浸润相关","authors":"Ying Liu, Linyuan Feng, Yang Yang, Zhenhua Lin, Wen-zheng Jiang","doi":"10.1166/jbt.2023.3256","DOIUrl":null,"url":null,"abstract":"Background: To explore expression and immune infiltration of SPARC/osteonectin, cwcv, and maze-like domains proteoglycan 1 (SPOCK1) in Head and Neck squamous cell carcinoma. Methods: A total of 107 HNSC patients’ tissues and 15 adjacent normal tissues were collected\n in this study. Co-expressed gene and gene set enrichment analysis was detected using STRING and Linked Omics. Immune cell infiltration related to SPOCK1 was analyzed via TIMER. Results: The positive rate of SPOCK1 in HNSC tissues were significantly higher than that in normal tissues\n by immunohistochemical staining (p< 0.01). The expression of SPOCK1 in HNSC was a positive correlation with the level of immune infiltrating cells. In addition, we discovered that SPOCK1 was major involved in inflammatory response pathways, cancer cell proliferation regulation, cell\n cycle regulation, apoptosis, adhesion, cell-matrix interaction, etc. Conclusions: SPOCK1 plays a role in promoting cancer in HNSC, which was closely related to the malignant evolution of HNSC, and it was expected to become a prognostic molecular marker for HNSC patients and a potential\n target for immunotherapy.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":"1 1","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SPOCK1 is a Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Head and Neck Squamous Cell Carcinoma\",\"authors\":\"Ying Liu, Linyuan Feng, Yang Yang, Zhenhua Lin, Wen-zheng Jiang\",\"doi\":\"10.1166/jbt.2023.3256\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: To explore expression and immune infiltration of SPARC/osteonectin, cwcv, and maze-like domains proteoglycan 1 (SPOCK1) in Head and Neck squamous cell carcinoma. Methods: A total of 107 HNSC patients’ tissues and 15 adjacent normal tissues were collected\\n in this study. Co-expressed gene and gene set enrichment analysis was detected using STRING and Linked Omics. Immune cell infiltration related to SPOCK1 was analyzed via TIMER. Results: The positive rate of SPOCK1 in HNSC tissues were significantly higher than that in normal tissues\\n by immunohistochemical staining (p< 0.01). The expression of SPOCK1 in HNSC was a positive correlation with the level of immune infiltrating cells. In addition, we discovered that SPOCK1 was major involved in inflammatory response pathways, cancer cell proliferation regulation, cell\\n cycle regulation, apoptosis, adhesion, cell-matrix interaction, etc. Conclusions: SPOCK1 plays a role in promoting cancer in HNSC, which was closely related to the malignant evolution of HNSC, and it was expected to become a prognostic molecular marker for HNSC patients and a potential\\n target for immunotherapy.\",\"PeriodicalId\":15300,\"journal\":{\"name\":\"Journal of Biomaterials and Tissue Engineering\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials and Tissue Engineering\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1166/jbt.2023.3256\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials and Tissue Engineering","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1166/jbt.2023.3256","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SPOCK1 is a Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Head and Neck Squamous Cell Carcinoma
Background: To explore expression and immune infiltration of SPARC/osteonectin, cwcv, and maze-like domains proteoglycan 1 (SPOCK1) in Head and Neck squamous cell carcinoma. Methods: A total of 107 HNSC patients’ tissues and 15 adjacent normal tissues were collected
in this study. Co-expressed gene and gene set enrichment analysis was detected using STRING and Linked Omics. Immune cell infiltration related to SPOCK1 was analyzed via TIMER. Results: The positive rate of SPOCK1 in HNSC tissues were significantly higher than that in normal tissues
by immunohistochemical staining (p< 0.01). The expression of SPOCK1 in HNSC was a positive correlation with the level of immune infiltrating cells. In addition, we discovered that SPOCK1 was major involved in inflammatory response pathways, cancer cell proliferation regulation, cell
cycle regulation, apoptosis, adhesion, cell-matrix interaction, etc. Conclusions: SPOCK1 plays a role in promoting cancer in HNSC, which was closely related to the malignant evolution of HNSC, and it was expected to become a prognostic molecular marker for HNSC patients and a potential
target for immunotherapy.