聚乳酸胶乳颗粒表面接枝多肽链的构象研究

4区材料科学 Q2 Engineering

Advances in Materials Science and Engineering Pub Date : 2009-10-20 DOI:10.1155/2009/196950

S. Tanimoto, Toshiya Iwata, H. Yamaoka, M. Yamada, Kana Kobori

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引用次数: 2

摘要

以聚乳酸(PLA)和聚乳酸-嵌段多肽共聚物为原料，采用溶剂交换法制备了覆盖多肽链的聚乳酸(PLA)胶乳颗粒。嵌段共聚物的PLA段与PLA均聚物形成颗粒核，嵌段共聚物的多肽段被设计为紧密固定的可生物降解乳化剂，在颗粒表面周围形成电晕。由于多肽链中存在可电离基团，覆盖多肽段的聚乳酸乳胶颗粒的ζ电位与裸聚乳酸颗粒的ζ电位不同。为了阐明可电离基团对多肽链构象的影响，我们对多肽链长度与单链所占面积的关系进行了评价。多肽链的占据面积随多肽链长度的增加而线性增加，表明多肽链在颗粒表面呈拖尾状，不呈螺旋状结构。

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Conformational Study of Polypeptide Chains Grafted on the Surface of Polylactide Latex Particle

Polylactide (PLA) latex particle covered with polypeptide chains were prepared by means of solvent exchange method from PLA and PLA-block-polypeptide block copolymer solutions. PLA segment of the block copolymer and PLA homopolymer formed a core of the particle, and the polypeptide segment of the block copolymer, which is designed as tightly fixed biodegradable emulsifier, formed corona around the particle surface. This picture was supported by the fact that zeta-potential of PLA latex particle covered with polypeptide segment was different from that of bare PLA particle because of the presence of the ionizable group in the polypeptide chains. To clarify the effect of the ionizable group on conformation of the polypeptide chain, the relation between the polypeptide chain length and the area occupied by the single block chain was evaluated. The result that the occupied area per a polypeptide chain was linearly increased with the increase in the polypeptide chain length indicates that the polypeptide chains trail on the particle surface and did not take helical structures.

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来源期刊

Advances in Materials Science and Engineering Materials Science-General Materials Science

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Advances in Materials Science and Engineering is a broad scope journal that publishes articles in all areas of materials science and engineering including, but not limited to: -Chemistry and fundamental properties of matter -Material synthesis, fabrication, manufacture, and processing -Magnetic, electrical, thermal, and optical properties of materials -Strength, durability, and mechanical behaviour of materials -Consideration of materials in structural design, modelling, and engineering -Green and renewable materials, and consideration of materials’ life cycles -Materials in specialist applications (such as medicine, energy, aerospace, and nanotechnology)