SENSORIMOTOR NEUROLOGY

bromide content in blood the inference is drawn that in following patients under bromide treatment it is the clinical features, and not the laboratory findings, that one should primarily reckon with in regard to the menace of bromide intoxication. However, when the blood bromide reaches a concentration neighbouring on 250 mig. per cent. the patient should be closely observed, for in most of those in whom abnormal findings could be elicited on clinical examination, the blood bromide was found to be near and above this level. The determination of the bromide permeability quotient cannot be used as a test of tolerance to bromide. The results obtained by these investigators do not corroborate the contention that substances introduced into the general circulation should first penetrate into the cerebrospinal fluid in order to affect the cerebrospinal nervous system. C. S. R.