同种异体干细胞移植受者在GCV先发制人治疗后，巨细胞病毒UL97突变导致更昔洛韦(GCV)耐药性的缺失

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2001-12-01 DOI:10.1128/AAC.45.12.3669-3671.2001

C. Gilbert, J. Roy, R. Bélanger, R. Delage, C. Béliveau, C. Demers, G. Boivin

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引用次数: 39

摘要

50名同种异体干细胞移植受者参加了一项巨细胞病毒pp65抗原引导的前瞻性先发制人治疗试验。其中，接受更昔洛韦治疗的34例患者中有10例表现出持续和/或复发性抗原血症。从这10名受试者中筛选13种白细胞制剂，以确定是否存在最常见的巨细胞病毒UL97突变，从而产生更昔洛韦耐药性。在更昔洛韦暴露的平均和中位数分别为31.6天和28.0天后，没有检测到这些突变。

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Lack of Emergence of Cytomegalovirus UL97 Mutations Conferring Ganciclovir (GCV) Resistance following Preemptive GCV Therapy in Allogeneic Stem Cell Transplant Recipients

ABSTRACT Fifty allogeneic stem cell transplant recipients were enrolled in a prospective cytomegalovirus pp65 antigenemia-guided preemptive therapy trial. Among these, 10 of 34 patients who received ganciclovir exhibited sustained and/or recurrent antigenemia despite treatment. Thirteen leukocyte preparations from these 10 subjects were screened for the presence of the most frequent cytomegalovirus UL97 mutations conferring ganciclovir resistance. None of these mutations were detected after mean and median ganciclovir exposures of 31.6 and 28.0 days, respectively.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.