BARBARA BOBROWSKA, ANDRZEJ TOKARZ, GRZEGORZ GRYNKIEWICZ, SŁAWOMIR BIALEK, MAGDALENA MATYSIAK, TSERENDEJID BAT-ERDENE
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THE EFFECT OF POLYPHENOLS ON MARKERS OF OXIDATIVE DAMAGE AND DMBA-INDUCED CARCINOGENESIS IN RATS
ABSTRACT
The correlation between diets supplemented with resveratrol, genistein or quercetin on oxidative damage to proteins, lipids and nucleic acids was examined. Moreover, the rate of formation of changes resulting from carcinogenesis induced by 7,8-dimethylbenz[a]anthracene (DMBA) was assessed. The results for the impact of selected polyphenolic compounds on the intensity of DMBA-induced carcinogenesis were also presented. The polyphenols used, namely resveratrol, genistein and quercetin measured by the concentration of selected biomarkers related to their antioxidant properties and the impact of DMBA and fatty acids in rapeseed oil as well as of progression stage of the cancer process, were also significant.
PRACTICAL APPLICATIONS
The estimation of the impact of selected polyphenolic compounds on the intensity of 7,8-dimethylbenz[a]anthracene-induced carcinogenesis and oxidative damage to proteins, lipids and nucleic acids in rats was examined. Identifying the results of polyphenol activity in selected doses and different suspensions may allow application of these dietary compounds in human cancer prevention or for improvement of pharmacological treatment.
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