Neurological adverse effects of cancer chemotherapy

SummaryNeurological adverse events can be broadly divided into those affecting the central nervous system and those affecting the peripheral nervous system. Chemotherapy-induced neurological adverse effects can reduce treatment efficacy or lead to treatment failure, and can impair the patient's quality of life. Neurotoxicity is more likely when chemotherapy is combined with radiotherapy. Concomitantly prescribed supportive therapy, and the disease itself, can make it difficult to identify the cause of neurological adverse effects. However, the type and degree of toxicity has been shown to be related to the drug type, dose-intensity and cumulative dosage.