{"title":"常染色体显性急性卟啉症的安全处方:一种实用方法:第二部分","authors":"Cerys D. Lockett, M. Badminton","doi":"10.1097/fad.0000000000000012","DOIUrl":null,"url":null,"abstract":"SummaryThe autosomal dominant acute hepatic porphyrias – principally acute intermittent porphyria, variegate porphyria, and hereditary coproporphyria – can present with potentially fatal acute neurological crisis as a consequence of exposure to various precipitants including legal and illegal drugs. Part 1 of this review covered the assessment of drugs’ porphyinogenicity and described grading systems that are in use worldwide. Part 2 covers the complex safety assessments that should be undertaken when deciding whether drug treatment is appropriate or not. A clinical porphyria specialist can provide help in these circumstances.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"294 1","pages":"1135–1138"},"PeriodicalIF":0.0000,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/fad.0000000000000012","citationCount":"0","resultStr":"{\"title\":\"Safe prescribing in the autosomal dominant acute porphyrias: a practical approach: Part II\",\"authors\":\"Cerys D. Lockett, M. Badminton\",\"doi\":\"10.1097/fad.0000000000000012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"SummaryThe autosomal dominant acute hepatic porphyrias – principally acute intermittent porphyria, variegate porphyria, and hereditary coproporphyria – can present with potentially fatal acute neurological crisis as a consequence of exposure to various precipitants including legal and illegal drugs. Part 1 of this review covered the assessment of drugs’ porphyinogenicity and described grading systems that are in use worldwide. Part 2 covers the complex safety assessments that should be undertaken when deciding whether drug treatment is appropriate or not. A clinical porphyria specialist can provide help in these circumstances.\",\"PeriodicalId\":39261,\"journal\":{\"name\":\"Adverse Drug Reaction Bulletin\",\"volume\":\"294 1\",\"pages\":\"1135–1138\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1097/fad.0000000000000012\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Adverse Drug Reaction Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/fad.0000000000000012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Adverse Drug Reaction Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/fad.0000000000000012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Safe prescribing in the autosomal dominant acute porphyrias: a practical approach: Part II
SummaryThe autosomal dominant acute hepatic porphyrias – principally acute intermittent porphyria, variegate porphyria, and hereditary coproporphyria – can present with potentially fatal acute neurological crisis as a consequence of exposure to various precipitants including legal and illegal drugs. Part 1 of this review covered the assessment of drugs’ porphyinogenicity and described grading systems that are in use worldwide. Part 2 covers the complex safety assessments that should be undertaken when deciding whether drug treatment is appropriate or not. A clinical porphyria specialist can provide help in these circumstances.
期刊介绍:
For over 40 years, Adverse Drug Reaction Bulletin has provided comprehensive coverage in the field of adverse drug reactions. Each issue contains an invited article on a topic of current interest, dealing with specific conditions from drug-induced lung disorders to drug-induced sexual dysfunction, or types of drugs from lipid-lowering agents to poisons antidotes. This bimonthly journal"s articles are timely, succinct and fully referenced