抗胆碱能药物治疗阻塞性肺疾病的不良反应

Q4 Medicine

Adverse Drug Reaction Bulletin Pub Date : 2015-04-01 DOI:10.1097/FAD.0000000000000009

Christopher M. Jones, Lucy M.R. Nell

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引用次数: 0

摘要

毒蕈碱类乙酰胆碱受体拮抗剂广泛应用于阻塞性气道疾病的治疗。然而，只有有限的证据表明这些受体拮抗剂可以改善预后，并且它们的使用因影响许多器官系统的全身不良反应而复杂化。当代的抗胆碱能药物引起的不良反应较少，其系统生物利用度也低于其前身，但其使用可能与心血管发病率和死亡率的增加有关。

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Adverse reactions to anticholinergic agents used in the management of obstructive pulmonary disease

SummaryMuscarinic acetylcholine receptor antagonists are widely used in the management of obstructive airways disease. There nevertheless exists only limited evidence that these receptor antagonists improve prognosis and their use is complicated by systemic adverse reactions affecting many organ systems. Contemporary anticholinergic agents cause fewer adverse reactions and have lower systemic bioavailability than their predecessors, yet their use may be associated with increased cardiovascular morbidity and mortality.

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来源期刊

Adverse Drug Reaction Bulletin Medicine-Pharmacology (medical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： For over 40 years, Adverse Drug Reaction Bulletin has provided comprehensive coverage in the field of adverse drug reactions. Each issue contains an invited article on a topic of current interest, dealing with specific conditions from drug-induced lung disorders to drug-induced sexual dysfunction, or types of drugs from lipid-lowering agents to poisons antidotes. This bimonthly journal"s articles are timely, succinct and fully referenced