微生物组作为HIV感染者肛门癌前病变的生物标志物。

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-02-01 Epub Date: 2023-10-27 DOI:10.1097/QCO.0000000000000985

Raquel Ron, Elena Moreno, Marta Rosas Cancio-Suárez, Sergio Serrano-Villar

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引用次数: 0

摘要

综述目的：早期发现和治疗某些高危人群中与人乳头瘤病毒（HPV）相关的肛门发育不良可以帮助预防肛门癌症，但需要新的工具来改进诊断和风险评估。在此，我们旨在讨论微生物组作为HIV（PWH）患者肛门高级鳞状上皮内病变（HSIL）潜在生物标志物的作用的证据。最新研究结果：本综述涵盖了微生物组与HPV感染、宫颈发育不良/癌症和肛门HPV疾病之间联系的相关研究。它关注肛门样本和癌前病变。综述：这篇综述强调了肛门微生物组作为HIV患者癌前病变的新生物标志物的潜力，同时也讨论了其局限性和未来的研究需求。

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The microbiome as a biomarker of anal precancerous lesions in people with HIV.

Purpose of review: Early detection and treatment of human papillomavirus (HPV)-related anal dysplasia in some high-risk groups can help anal cancer prevention, but new tools to improve diagnostic and risk assessment are needed. Here, we aim to discuss the evidence on the role of the microbiome as a potential biomarker for anal high-grade squamous intraepithelial lesions (HSILs) in people with HIV (PWH).

Recent findings: This review covers relevant studies on the links between the microbiome and HPV infection, cervical dysplasia/cancer, and anal HPV disease. It focuses on anal samples and precancerous lesions.

Summary: The review highlights the promising potential of the anal microbiome as a novel biomarker for precancerous lesions in people with HIV, while also discussing limitations and future research needs.

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.