动物模型对糖尿病研究的贡献:历史、意义和对人类的转化

IF 3.2 3区 医学
Soroku Yagihashi
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引用次数: 2

摘要

糖尿病仍在全球范围内蔓延,并在发展中国家流行。与这一瘟疫的斗争造成了与糖尿病患者生活质量下降有关的巨大经济和社会负担。尽管最近糖尿病患者的预期寿命显著改善,但仍需要努力阐明疾病过程的复杂性和机制,以克服这一困难的疾病。为此,在糖尿病研究中使用适当的动物模型对于转化为人类和开发有效的治疗方法是非常宝贵的。在这篇综述中,我们将介绍各种各样的糖尿病动物模型,特别是自发性发作的糖尿病动物模型,并讨论它们在糖尿病研究中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Contribution of animal models to diabetes research: Its history, significance, and translation to humans

Contribution of animal models to diabetes research: Its history, significance, and translation to humans

Diabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes. Despite recent significant improvements of life expectancy in patients with diabetes, there is still a need for efforts to elucidate the complexities and mechanisms of the disease processes to overcome this difficult disorder. To this end, the use of appropriate animal models in diabetes studies is invaluable for translation to humans and for the development of effective treatment. In this review, a variety of animal models of diabetes with spontaneous onset in particular will be introduced and discussed for their implication in diabetes research.

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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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