子宫-阴道胚胎发生的新理论

IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Z. Makiyan
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引用次数: 19

摘要

背景:人类子宫和阴道胚胎发生的解释仍然存在许多争议,因为很难评估胚胎的早期阶段。文献综述揭示了缪勒理论中存在的诸多分歧,促使一些作者提出了新的胚胎学假说。在最初的缪勒氏理论中:肾旁管构成输卵管、子宫和阴道;在雌性胚胎中,中肾管退化。目的:本文的目的是通过对基础胚胎学理论和各种子宫阴道异常的比较分析来研究人类缪勒管的发育。材料和方法:1998年至2015年间,莫斯科妇产科科学中心对434名患有各种子宫阴道畸形的患者进行了手术。这些患者的子宫阴道畸形解剖是通过超声和MRI诊断的,然后在腹腔镜手术矫正中得到证实。结果:将子宫阴道畸形与文献中的畸形进行系统比较,使我们能够形成一种新的胚胎形态发生理论。新的理论有明显的不同:卵巢、卵巢固有韧带和子宫圆韧带起源于性腺脊;输卵管和阴道完全由肾系膜管发育而来。子宫发育在肾系管与性腺脊的交汇处,两者融合而成。结论:这一新理论可能为今后的胚胎学研究提供指导。卵巢和子宫内膜起源于性腺脊的假设可能是理解子宫外和卵巢子宫内膜异位症神秘病因的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New theory of uterovaginal embryogenesis
ABSTRACT Background: The explanation of uterine and vaginal embryogenesis in humans still poses many controversies, because it is difficult to assess early stages of an embryo. The literature review revealed many disagreements in Mullerian theory, inciting some authors to propose new embryological hypotheses. In the original Mullerian theory: the paramesonephral ducts form the Fallopian tubes, uterus and vagina; the mesonephral ducts regress in female embryos. Aims: The aim of this article is to investigate the development of Mullerian ducts in humans, using comparative analysis of fundamental embryological theory and various utero-vaginal anomalies. Material and methods: Between 1998 and 2015, 434 patients with various uterovaginal malformations had been operated on at the Scientific Centre of Obstetrics Gynaecology and Perynatology in Moscow. The anatomies of the uterovaginal malformations in these patients were diagnosed with ultrasound and MRI and then verified during surgical correction by laparoscopy. Results: A systematic comparison of uterovaginal malformations to those in the literature has allowed us to formulate a new theory of embryonic morphogenesis. The new theory is significantly different: ovary, ovarian ligamentum proprium, and ligamentum teres uteri derive from gonadal ridges; Fallopian tubes and vagina completely develop from mesonephral ducts. The uterus develops in the area of intersection between the mesonephral ducts with gonadal ridges by the fusion of the two. Conclusions: The new theory may to induce future embryological studies. The hypothetic possibility that the ovary and endometrium derive from the gonadal ridges could be the key to understanding the enigmatic aetiologies of extragenital and ovarian endometriosis.
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来源期刊
Organogenesis
Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY
CiteScore
4.10
自引率
4.30%
发文量
6
审稿时长
>12 weeks
期刊介绍: Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.
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