Wnt-YAP在人类多能干细胞神经命运中的相互作用及其对神经类器官形成的影响

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2016-01-02 DOI:10.1080/15476278.2016.1140290

Julie Bejoy, Liqing Song, Yan Li

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引用次数: 12

摘要

近年来，人类多能干细胞(hPSCs)显示出自组织成不同类型神经类器官的能力(如全脑类器官、皮质球类器官、中脑类器官等)。Wnt通路、Hippo/Yes-associated protein (YAP)通路和细胞外微环境诱导的外源性和内源性信号在脑组织形态发生中起着至关重要的作用。本文重点介绍了从hPSCs中提取神经组织模式的最新进展，特别是Wnt通路和YAP活性在这一过程中的作用。了解Wnt-YAP的相互作用将为我们通过调控hPSCs的细胞外微环境来预测和调节脑样组织结构提供指导。

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Wnt-YAP interactions in the neural fate of human pluripotent stem cells and the implications for neural organoid formation

ABSTRACT Human pluripotent stem cells (hPSCs) have shown the ability to self-organize into different types of neural organoids (e.g., whole brain organoids, cortical spheroids, midbrain organoids etc.) recently. The extrinsic and intrinsic signaling elicited by Wnt pathway, Hippo/Yes-associated protein (YAP) pathway, and extracellular microenvironment plays a critical role in brain tissue morphogenesis. This article highlights recent advances in neural tissue patterning from hPSCs, in particular the role of Wnt pathway and YAP activity in this process. Understanding the Wnt-YAP interactions should provide us the guidance to predict and modulate brain-like tissue structure through the regulation of extracellular microenvironment of hPSCs.

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.