高效液相色谱法鉴定反式吲哚酰- 3 -丙烯酰甘氨酸与广泛性发育障碍相关的原因是什么?

P. Whiteley, P. MRPharmS
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引用次数: 3

摘要

目的:评估广泛性发育障碍(PDD)患者尿液中反式吲哚酰- 3 -丙烯酰甘氨酸(IAcrGly)与对照组的患病率。设计:尿中acrly水平的病例对照研究。材料和方法:对500例正式诊断为PDD(自闭症、阿斯伯格综合征和自闭症谱系障碍)和对照组(未诊断)的患者的发育、当前医疗状况和尿液结果的电子记录进行检查,以确定是否存在通过梯度洗脱高效液相色谱(HPLC)鉴定的尿液iacrgy、癫痫共发病情况和当前用药情况。结果:与对照组相比,PDD组中更多的样本中发现了尿acrgly,尽管这并不显著(p=0.063, Fisher精确检验,双侧)。然而,PDD组伴随的癫痫疾病发生率和已知影响HPLC结果的药物使用情况也显著高于PDD组(χ2=8.070, df=1, p<0.004) (χ2=4.203,…
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What Makes Trans‐indolyl‐3‐acryloylglycine Identified by High‐performance Liquid Chromatography Relevant to Pervasive Developmental Disorders?
Purpose: To assess the prevalence of trans‐indolyl‐3‐acryloylglycine (IAcrGly) in the urine of people with a pervasive developmental disorder (PDD) compared with controls.Design: A case–control study of urinary IAcrGly levels.Materials and Methods: The electronic records of developmental and current medical status and urinary results of 500 patients formally diagnosed with PDD (autism, Asperger syndrome and autism spectrum disorder) and controls (no diagnosis) were examined for the presence of urinary IAcrGly identified by gradient elution high‐performance liquid chromatography (HPLC), co‐morbidity of epilepsy and current use of medication.Results: Urinary IAcrGly was identified in more samples from the PDD groups than the controls, although this was not significant (p=0.063, Fisher's exact test, two‐sided). The accompanying rates of epileptic disorders and current use of medication known to affect HPLC results were, however, also significantly higher in the PDD groups (χ2=8.070, df=1, p<0.004) (χ2=4.203,...
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