具有抗糖化活性的小合成分子。结构与活性关系

IF 7 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Reviews Pub Date : 2022-01-01 DOI:10.1070/RCR5041

K. Savateev, A. Spasov, V. Rusinov

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引用次数: 2

摘要

晚期糖基化终产物(AGEs)的积累目前被认为是衰老过程的关键因素之一，也是糖尿病、癌症和神经退行性疾病晚期并发症的发病机制之一。本综述致力于具有抗糖化活性的小合成分子，即具有抑制AGE形成能力的化合物。在低微摩尔范围(<10 μM)具有抗糖基化活性的分子，主要是含有氧或氮作为杂原子和(硫)脲的融合杂环体系，迄今已被发现。对已知的具有抗糖化活性的支架进行了分析，重点介绍了增强抗糖化能力的结构修饰，并讨论了结构-活性关系。参考书目包括125篇参考文献。

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Small synthetic molecules with antiglycation activity. Structure–activity relationship

The accumulation of advanced glycation end products (AGEs) is currently considered as one of the key factors in aging processes, the pathogenesis of late complications of diabetes mellitus, cancer and neurodegenerative diseases. This review is devoted to small synthetic molecules with antiglycation activity, i.e., compounds with the ability to inhibit AGE formation. Molecules with antiglycation activity in the low micromolar range (<10 μM), primarily fused heterocyclic systems containing oxygen or nitrogen as heteroatoms and (thio)ureas, have been discovered to date. The known scaffolds with antiglycation activity are analyzed, structural modifications to enhance antiglycation abilities are highlighted and the structure–activity relationships are discussed. The bibliography includes 125 references.

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来源期刊

Russian Chemical Reviews 化学-化学综合

CiteScore

13.00

自引率

5.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Russian Chemical Reviews serves as a complete translation of the esteemed monthly review journal Uspekhi Khimii, which has been a prominent figure in Russian scientific journals since its establishment in 1932. It offers comprehensive access to the advancements made by chemists from Russia and other former Soviet Union countries. Established in 1932, Russian Chemical Reviews is committed to publishing timely and significant review articles encompassing various facets of modern chemistry, including chemical physics, physical chemistry, computational and theoretical chemistry, catalysis, coordination chemistry, analytical chemistry, organic, organometallic, and organoelement chemistry, chemistry of macromolecules, applied chemistry, biochemistry, bio-organic chemistry, biomolecular chemistry, medicinal chemistry, materials chemistry, nanochemistry, nanostructures, and environmental chemistry.