BODIPY衍生物作为活细胞分子活动的荧光报告者

IF 7 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Reviews Pub Date : 2021-01-01 DOI:10.1070/RCR4985

V. Martynov, A. A. Pakhomov

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引用次数: 8

摘要

荧光化合物已成为成像活细胞分子活动不可缺少的工具。4,4-二氟-4-硼-3a,4 -二氮杂-s-茚二烯(BODIPY)由于其独特的光物理性质是目前最受欢迎的荧光报告分子之一。本文综述了近年来基于bodip的细胞生物标志物和生物传感器的研究进展。回顾从考虑BODIPY衍生物作为细胞报告者应用所需的性质开始。然后，综述提供了传感器的设计实例，用于定义活细胞状态的不同生物重要分子、离子、膜电位、温度和粘度。特别注意的是基于bodp的光变形记者。参考书目包括339篇参考文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BODIPY derivatives as fluorescent reporters of molecular activities in living cells

Fluorescent compounds have become indispensable tools for imaging molecular activities in the living cell. 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) is currently one of the most popular fluorescent reporters due to its unique photophysical properties. This review provides a general survey and presents a summary of recent advances in the development of new BODIPY-based cellular biomarkers and biosensors. The review starts with the consideration of the properties of BODIPY derivatives required for their application as cellular reporters. Then review provides examples of the design of sensors for different biologically important molecules, ions, membrane potential, temperature and viscosity defining the live cell status. Special attention is payed to BODPY-based phototransformable reporters. The bibliography includes 339 references.

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来源期刊

Russian Chemical Reviews 化学-化学综合

CiteScore

13.00

自引率

5.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Russian Chemical Reviews serves as a complete translation of the esteemed monthly review journal Uspekhi Khimii, which has been a prominent figure in Russian scientific journals since its establishment in 1932. It offers comprehensive access to the advancements made by chemists from Russia and other former Soviet Union countries. Established in 1932, Russian Chemical Reviews is committed to publishing timely and significant review articles encompassing various facets of modern chemistry, including chemical physics, physical chemistry, computational and theoretical chemistry, catalysis, coordination chemistry, analytical chemistry, organic, organometallic, and organoelement chemistry, chemistry of macromolecules, applied chemistry, biochemistry, bio-organic chemistry, biomolecular chemistry, medicinal chemistry, materials chemistry, nanochemistry, nanostructures, and environmental chemistry.