中性粒细胞是粘膜免疫的守门人

IF 7.5 2区医学 Q1 IMMUNOLOGY

Immunological Reviews Pub Date : 2022-11-20 DOI:10.1111/imr.13171

Lakmali M. Silva, Tae Sung Kim, Niki M. Moutsopoulos

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引用次数: 4

摘要

粘膜组织经常暴露在外界环境中。它们接收来自共生微生物群和组织特异性触发因素(包括食物和空气因素)的信号，并负责在没有炎症和感染的情况下维持平衡。在这里，我们提出中性粒细胞作为粘膜免疫的前哨细胞。我们讨论了中性粒细胞在粘膜稳态中的作用，并概述了中性粒细胞缺陷患者的临床易感性。最后，我们提出了与特定粘膜组织微环境中中性粒细胞反应规范相关的概念。

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Neutrophils are gatekeepers of mucosal immunity

Mucosal tissues are constantly exposed to the outside environment. They receive signals from the commensal microbiome and tissue-specific triggers including alimentary and airborne elements and are tasked to maintain balance in the absence of inflammation and infection. Here, we present neutrophils as sentinel cells in mucosal immunity. We discuss the roles of neutrophils in mucosal homeostasis and overview clinical susceptibilities in patients with neutrophil defects. Finally, we present concepts related to specification of neutrophil responses within specific mucosal tissue microenvironments.

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来源期刊

Immunological Reviews 医学-免疫学

CiteScore

16.20

自引率

1.10%

发文量

118

审稿时长

4-8 weeks

期刊介绍： Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.