欧洲心脏病学会血脂异常临床实践指南的更新:证据的权重

Q4 Medicine
Carlos Escobar , Vivencio Barrios
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引用次数: 0

摘要

自2016年以来,关键clínical试验(如FOURIER和ODYSSEY OUTCOMES试验)以及其他类型clínical研究的发表,导致了针对血脂异常患者的clínical实践指南的变化,该指南于2019年更新。心血管风险分层已通过以下方法得到改善:(i)无创心血管成像,例如冠状动脉钙评分、颈动脉或股动脉超声检查和冠状动脉CT血管造影;生物标志物,特别是脂蛋白(a)。然而,主要的新颖之处是更严格的低密度脂蛋白胆固醇治疗靶点,以及在他汀类药物的基础上添加依折替米和蛋白转化酶枯草杆菌素/kexin 9型(PCSK9)抑制剂的新建议,这两种抑制剂现在已成为一级治疗建议。此外,西班牙心脏病学会关于改善继发性prevención血脂控制的共识为优化降脂治疗提供了一种简单实用的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novedades en la guía de práctica clínica de la Sociedad Europea de Cardiología en dislipemias: el peso de la evidencia

The publication of pivotal clínical trials, such as the FOURIER and ODYSSEY OUTCOMES trials, and of other types of clínical study since 2016 has resulted in changes in the clínical practice guidelines for patients with dyslipidemias, which were updated in 2019. Cardiovascular risk stratification has been improved by the use of: (i) noninvasive cardiovascular imaging, involving for example the coronary calcium score, carotid or femoral artery ultrasonography, and coronary CT angiography; and (ii) biomarkers, particularly lipoprotein(a). However, the principle novelties were much stricter low-density lipoprotein cholesterol treatment targets and new recommendations on ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, added to statins, which have now become class-I treatment recommendations. Furthermore, the Spanish Society of Cardiology’s consensus on improving lipid control in secondary prevención provides a simple and practical way of optimizing lipid-lowering therapy.

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来源期刊
Revista Espanola de Cardiologia Suplementos
Revista Espanola de Cardiologia Suplementos Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.20
自引率
0.00%
发文量
1
期刊介绍: Revista Española de Cardiología, is an international scientific journal dealing with cardiovascular medicine. Revista Española de Cardiología, the official publication of the Spanish Society of Cardiology, publishes research articles related to cardiovascular diseases. Articles are published in Spanish for the paper edition and in both Spanish and English in the electronic edition, which is available on the Internet. Regular sections include original articles reporting clinical or basic research, brief reports, review articles, editorials and letters to the Editor.
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