M.C. Villa-Corbatón , L. Callol-Sánchez , J. Medina-Font , J. Gómez de Terreros-Sánchez , C. Gutiérrez-Ortega , J. Gómez de Terreros-Caro
{"title":"健康和慢性阻塞性肺病吸烟者中C反应蛋白的分析以及共病和戒烟时间的影响","authors":"M.C. Villa-Corbatón , L. Callol-Sánchez , J. Medina-Font , J. Gómez de Terreros-Sánchez , C. Gutiérrez-Ortega , J. Gómez de Terreros-Caro","doi":"10.1016/S1576-9895(12)70154-6","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The smoking habit increases the C reactive protein in the serum. Values are studied in different populations: healthy (exsmokers, smokers and nonsmokers), chronic bronchitis and chronic obstructive pulmonary disease (COPD) in different stages; in addition the influence according to the time of abandonment of the tobacco and the associate comorbidities.</p></div><div><h3>Material and methods</h3><p>Descriptive-transversal analysis. 401 persons we studied: 106 healthy not smokers (HNS), 104 healthy smokers (HS), 95 healthy nonsmoker (HN), 30 with chronic bronchitis, 30 with incipient COPD (COPDi) and 36 with advanced COPD (COPDa), with ages included between 45 and 80 years old, being detrmined CRP and the associate comorbidities.</p></div><div><h3>Results</h3><p>CRP's values were: 1.98 (2.1)<!--> <!-->mg/l in HN; 3.35 (4.39)<!--> <!-->mg/l in HS; 2 (2.2)<!--> <!-->mg/l in HE; 3 (3.8)<!--> <!-->mg/l in chronic bronchitis; 3.40 (2.23) in COPDi and 5.94 (1.76) in COPDa. The CRP in chronic bronchitis and COPD falls to 2.7 (6.8) after five years of abandonment of the tobacco, remaining constant after. There exist significant differences between the HS and HN populations, and between chronic bronchitis and COPD after five years of abstinence with the population HN (p=0.003). There are not significant differences between HE and HN (p<!--> <!-->><!--> <!-->0.05); between population HS and the population with chronic bronchitis and COPDi (p<!--> <!-->><!--> <!-->0.05), and between COPD's different stages and the indexes of comorbiditie.</p></div><div><h3>Conclusions</h3><p>The value of the CRP in the HS population is similar to that on the chronic bronchitis and COPDi population, but higher to that of the HN. After the abandon of the smoking habit, in HS the CRP returns to the value of the HN population. In the populations with pathologies is significantly elevated as compared to HN and not return to the HN level after five years of abstinence. Their level is independent of comorbidity index. The detection level of inflammatory disease is at a value of PCR: 3<!--> <!-->mg/l.</p></div>","PeriodicalId":37742,"journal":{"name":"Revista de Patologia Respiratoria","volume":"15 4","pages":"Pages 104-110"},"PeriodicalIF":0.0000,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1576-9895(12)70154-6","citationCount":"1","resultStr":"{\"title\":\"Análisis de la proteína C reactiva en la población fumadora sana y con EPOC e influencia de las comorbilidades y del tiempo de abandono del tabaco\",\"authors\":\"M.C. Villa-Corbatón , L. Callol-Sánchez , J. Medina-Font , J. Gómez de Terreros-Sánchez , C. Gutiérrez-Ortega , J. Gómez de Terreros-Caro\",\"doi\":\"10.1016/S1576-9895(12)70154-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The smoking habit increases the C reactive protein in the serum. Values are studied in different populations: healthy (exsmokers, smokers and nonsmokers), chronic bronchitis and chronic obstructive pulmonary disease (COPD) in different stages; in addition the influence according to the time of abandonment of the tobacco and the associate comorbidities.</p></div><div><h3>Material and methods</h3><p>Descriptive-transversal analysis. 401 persons we studied: 106 healthy not smokers (HNS), 104 healthy smokers (HS), 95 healthy nonsmoker (HN), 30 with chronic bronchitis, 30 with incipient COPD (COPDi) and 36 with advanced COPD (COPDa), with ages included between 45 and 80 years old, being detrmined CRP and the associate comorbidities.</p></div><div><h3>Results</h3><p>CRP's values were: 1.98 (2.1)<!--> <!-->mg/l in HN; 3.35 (4.39)<!--> <!-->mg/l in HS; 2 (2.2)<!--> <!-->mg/l in HE; 3 (3.8)<!--> <!-->mg/l in chronic bronchitis; 3.40 (2.23) in COPDi and 5.94 (1.76) in COPDa. The CRP in chronic bronchitis and COPD falls to 2.7 (6.8) after five years of abandonment of the tobacco, remaining constant after. There exist significant differences between the HS and HN populations, and between chronic bronchitis and COPD after five years of abstinence with the population HN (p=0.003). There are not significant differences between HE and HN (p<!--> <!-->><!--> <!-->0.05); between population HS and the population with chronic bronchitis and COPDi (p<!--> <!-->><!--> <!-->0.05), and between COPD's different stages and the indexes of comorbiditie.</p></div><div><h3>Conclusions</h3><p>The value of the CRP in the HS population is similar to that on the chronic bronchitis and COPDi population, but higher to that of the HN. After the abandon of the smoking habit, in HS the CRP returns to the value of the HN population. In the populations with pathologies is significantly elevated as compared to HN and not return to the HN level after five years of abstinence. Their level is independent of comorbidity index. 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Análisis de la proteína C reactiva en la población fumadora sana y con EPOC e influencia de las comorbilidades y del tiempo de abandono del tabaco
Objective
The smoking habit increases the C reactive protein in the serum. Values are studied in different populations: healthy (exsmokers, smokers and nonsmokers), chronic bronchitis and chronic obstructive pulmonary disease (COPD) in different stages; in addition the influence according to the time of abandonment of the tobacco and the associate comorbidities.
Material and methods
Descriptive-transversal analysis. 401 persons we studied: 106 healthy not smokers (HNS), 104 healthy smokers (HS), 95 healthy nonsmoker (HN), 30 with chronic bronchitis, 30 with incipient COPD (COPDi) and 36 with advanced COPD (COPDa), with ages included between 45 and 80 years old, being detrmined CRP and the associate comorbidities.
Results
CRP's values were: 1.98 (2.1) mg/l in HN; 3.35 (4.39) mg/l in HS; 2 (2.2) mg/l in HE; 3 (3.8) mg/l in chronic bronchitis; 3.40 (2.23) in COPDi and 5.94 (1.76) in COPDa. The CRP in chronic bronchitis and COPD falls to 2.7 (6.8) after five years of abandonment of the tobacco, remaining constant after. There exist significant differences between the HS and HN populations, and between chronic bronchitis and COPD after five years of abstinence with the population HN (p=0.003). There are not significant differences between HE and HN (p > 0.05); between population HS and the population with chronic bronchitis and COPDi (p > 0.05), and between COPD's different stages and the indexes of comorbiditie.
Conclusions
The value of the CRP in the HS population is similar to that on the chronic bronchitis and COPDi population, but higher to that of the HN. After the abandon of the smoking habit, in HS the CRP returns to the value of the HN population. In the populations with pathologies is significantly elevated as compared to HN and not return to the HN level after five years of abstinence. Their level is independent of comorbidity index. The detection level of inflammatory disease is at a value of PCR: 3 mg/l.
期刊介绍：
Revista de Patología Respiratoria is the scientific journal of the Madrilenian Pulmonology and Thoracic Surgery Society (Neumomadrid). It will consider those original articles related to Pulmonology, Thoracic Surgery and all other related sciences for their possible publication. Other types of articles such as reviews, editorials, special articles, scientific letters and letters to the editor are also published in the journal. It is a quarterly Journal that publishes a total of 4 issues, which contain these types of articles to different extents. All publications submitted will always undergo a peer review and a final decision will be made according to comments from the expert reviewers and members of the Editorial Board. The Journal is published both in Spanish and English. Therefore, the submission of manuscripts written in either Spanish or English is welcome.
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