人淋巴细胞自然杀伤、体外杀伤和抗体依赖性杀伤的阳离子需求

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-08-01 DOI:10.1016/S0340-904X(79)80058-5

S. Argov, A. Poros, E. Klein

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引用次数: 9

摘要

三种细胞毒性系统，NK, ADCC和体外活化淋巴细胞(用k562培养)的似乎不区分的细胞毒性需要Ca++，而在Mg+ +中不起作用。三种系统和不同淋巴细胞亚群的Ca+ +最佳浓度相同。相互作用开始15分钟后，三个系统的细胞都已发生损伤。

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Cation Requirement of Natural, In-Vitro Generated and Antibody Dependent Killing Exerted by Human Lymphocytes

Three cytotoxic systems, NK, ADCC and the seemingly indiscriminative cytotoxiciry of in vitro activated lymphocytes (cultivated with K 562) were found to require Ca++ and did not function in Mg^{+ +}. The optimum concentration of Ca^{+ +} was identical for the three systems and for various lymphocyte subsets.

15 minutes after initiation of the interaction cell damage had already occurred in all three systems.

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Zeitschrift für Immunit?tsforschung: Immunobiology

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