Sofie Hansen (Dr.) , Elisabeth Zemp , Robert Bettschart , Marco Pons , Thierry Rochat , Ayoung Jeong , Dirk Keidel , Christian Schindler , Nicole Probst-Hensch
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The main predictor of interest was self-reported body silhouettes at age 8, menarche, 30, 45, menopause, and 60, and additionally changes in body silhouette number across these different time points. Asthma incidence was defined as newly reported doctor-diagnosed asthma after the body silhouette time point. Asthma incidence and its association with body silhouettes was analysed using sex stratified logistic regression, adjusting for age, atopy, urbanity, smoking, parental asthma, education and study area.</p></div><div><h3>Results</h3><p>Men at age 60 had an increased risk of asthma incidence per unit increase in body silhouette number (OR 1.93, 95% CI 1.13–3.30). This association was stronger in women at age 60 (OR 2.78, 95% CI 1.49–5.18) and observed also at menopause (OR 1.35, 95% CI 1.03–1.78), as well as per unit change in body silhouette number between age 45 – menopause (OR 1.74, 95% CI 1.15–2.63).</p></div><div><h3>Conclusion</h3><p>In this longitudinal study, the risk of incident asthma increased in men and women with a larger body silhouette in late adulthood. In women, this risk appeared present between age 45 and menopause. At age 60, both men and women were at higher risk of asthma incidence per unit increase in body silhouette, the risk being more pronounced in women. The age-related increase of obesity may underlie gender differences in asthma incidence at higher ages.</p></div>","PeriodicalId":37129,"journal":{"name":"Respiratory Medicine: X","volume":"1 ","pages":"Article 100001"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.yrmex.2019.100001","citationCount":"0","resultStr":"{\"title\":\"Gender differences in the association between life history of body silhouettes and asthma incidence: Results from the SAPALDIA cohort study\",\"authors\":\"Sofie Hansen (Dr.) , Elisabeth Zemp , Robert Bettschart , Marco Pons , Thierry Rochat , Ayoung Jeong , Dirk Keidel , Christian Schindler , Nicole Probst-Hensch\",\"doi\":\"10.1016/j.yrmex.2019.100001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The association of obesity and asthma has been described in children and adults. However, whether a different life course of weight in men and women may explain gender differences in asthma incidence, has not been addressed.</p></div><div><h3>Objectives</h3><p>Using data from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, we investigated the role of overweight/obesity as measured by body silhouettes at different life stages in men and women for asthma incidence.</p></div><div><h3>Methods</h3><p>Our analysis included 5417 subjects who were asthma free at age 8, followed up to 2011, and had complete covariate information. The main predictor of interest was self-reported body silhouettes at age 8, menarche, 30, 45, menopause, and 60, and additionally changes in body silhouette number across these different time points. Asthma incidence was defined as newly reported doctor-diagnosed asthma after the body silhouette time point. Asthma incidence and its association with body silhouettes was analysed using sex stratified logistic regression, adjusting for age, atopy, urbanity, smoking, parental asthma, education and study area.</p></div><div><h3>Results</h3><p>Men at age 60 had an increased risk of asthma incidence per unit increase in body silhouette number (OR 1.93, 95% CI 1.13–3.30). This association was stronger in women at age 60 (OR 2.78, 95% CI 1.49–5.18) and observed also at menopause (OR 1.35, 95% CI 1.03–1.78), as well as per unit change in body silhouette number between age 45 – menopause (OR 1.74, 95% CI 1.15–2.63).</p></div><div><h3>Conclusion</h3><p>In this longitudinal study, the risk of incident asthma increased in men and women with a larger body silhouette in late adulthood. In women, this risk appeared present between age 45 and menopause. At age 60, both men and women were at higher risk of asthma incidence per unit increase in body silhouette, the risk being more pronounced in women. 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引用次数: 0
摘要
背景肥胖和哮喘的关联已经在儿童和成人中被描述过。然而，男性和女性体重的不同生活过程是否可以解释哮喘发病率的性别差异，尚未得到解决。目的:利用瑞士成人空气污染与心肺疾病队列研究的数据，我们调查了超重/肥胖在不同生命阶段对男性和女性哮喘发病率的作用。方法纳入5417名8岁时无哮喘的受试者，随访至2011年，具有完整的协变量信息。主要的预测因素是8岁、初潮、30岁、45岁、更年期和60岁时自我报告的身体轮廓，以及这些不同时间点的身体轮廓数变化。哮喘发病率定义为在身体轮廓时间点后新报告的医生诊断的哮喘。采用性别分层逻辑回归分析哮喘发病率及其与身体轮廓的关系，调整年龄、特应性、城市、吸烟、父母哮喘、教育程度和研究区域。结果60岁男性每单位身体廓形数增加，哮喘发病率增加(OR 1.93, 95% CI 1.13-3.30)。这种相关性在60岁的女性中更强(OR 2.78, 95% CI 1.49-5.18)，在绝经期(OR 1.35, 95% CI 1.03-1.78)，以及45岁至绝经期身体轮廓数的单位变化(OR 1.74, 95% CI 1.15-2.63)。结论:在这项纵向研究中，成年后期体型较大的男性和女性发生哮喘的风险增加。在女性中，这种风险出现在45岁到更年期之间。在60岁时，无论男性还是女性，每单位身体轮廓的增加都有更高的哮喘发病率风险，女性的风险更明显。与年龄相关的肥胖增加可能是高年龄哮喘发病率的性别差异的基础。
Gender differences in the association between life history of body silhouettes and asthma incidence: Results from the SAPALDIA cohort study
Background
The association of obesity and asthma has been described in children and adults. However, whether a different life course of weight in men and women may explain gender differences in asthma incidence, has not been addressed.
Objectives
Using data from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, we investigated the role of overweight/obesity as measured by body silhouettes at different life stages in men and women for asthma incidence.
Methods
Our analysis included 5417 subjects who were asthma free at age 8, followed up to 2011, and had complete covariate information. The main predictor of interest was self-reported body silhouettes at age 8, menarche, 30, 45, menopause, and 60, and additionally changes in body silhouette number across these different time points. Asthma incidence was defined as newly reported doctor-diagnosed asthma after the body silhouette time point. Asthma incidence and its association with body silhouettes was analysed using sex stratified logistic regression, adjusting for age, atopy, urbanity, smoking, parental asthma, education and study area.
Results
Men at age 60 had an increased risk of asthma incidence per unit increase in body silhouette number (OR 1.93, 95% CI 1.13–3.30). This association was stronger in women at age 60 (OR 2.78, 95% CI 1.49–5.18) and observed also at menopause (OR 1.35, 95% CI 1.03–1.78), as well as per unit change in body silhouette number between age 45 – menopause (OR 1.74, 95% CI 1.15–2.63).
Conclusion
In this longitudinal study, the risk of incident asthma increased in men and women with a larger body silhouette in late adulthood. In women, this risk appeared present between age 45 and menopause. At age 60, both men and women were at higher risk of asthma incidence per unit increase in body silhouette, the risk being more pronounced in women. The age-related increase of obesity may underlie gender differences in asthma incidence at higher ages.
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