一项在每日可耐受的烟酰胺上限范围内单次口服补充对健康受试者血液烟酰胺和NAD+水平的影响的非随机研究

Q2 Medicine
Takashi K. Ito , Tomohito Sato , Akio Hakamata , Yuki Onoda , Shumpei Sato , Fumiyoshi Yamazaki , Makoto Horikawa , Yutaka Takahashi , Takuya Kitamoto , Masako Suzuki , Shinya Uchida , Keiichi Odagiri , Mitsutoshi Setou
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引用次数: 8

摘要

烟酰胺腺嘌呤二核苷酸(NAD+)水平的下降是包括人类在内的多种生物衰老的标志。我们报告了一项人体临床试验,旨在评估单剂量补充烟酰胺(维生素B3的一种形式)对增加NAD+水平的功效。所有6名健康男性志愿者在每日可耐受上限(200毫克)内摄入烟酰胺导致全血最大浓度在0.5小时增加30倍,直到6小时持续下降。血液中烟酰胺增加了17%,而肾脏清除率只占摄入剂量的1.8%。NAD+浓度在12 h达到最大值,且各时间点均呈升高趋势。血液代谢组学分析表明,补充NAM后代谢组学变化持续24 h, 48 h后恢复到基线水平。全血NAD+基础水平在个体之间存在差异,与身高和烟酰胺单核苷酸(NMN)水平呈负相关。这些数据值得考虑进一步的临床评估,在安全剂量范围内重复剂量烟酰胺,以提高NAD+水平的效力和潜在的健康长寿益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of vitamin B3, on increasing NAD+ levels. Nicotinamide intake within the daily tolerable upper level (200 mg) led to the maximal whole blood concentration by a 30-fold increase at 0.5 h with a consistent decrease until 6 h in all 6 healthy male volunteers. The increase in blood nicotinamide amounted to 17%, whereas renal clearance accounted for 1.8% of the ingested dose. NAD+ levels reached a maximum concentration at 12 h, with all time points showing a trend of increase. Blood metabolome assay indicates that the metabolomic changes with NAM supplementation lasted 24 h and then returned to baseline by 48 h. The basal levels of whole blood NAD+ varied among individuals with a negative correlation with body height as well as nicotinamide mononucleotide (NMN) levels. These data warrant consideration for further clinical evaluation with repeated doses of nicotinamide within the safety dose range for the potency to increase NAD+ levels and potential accompanying benefits for healthy longevity.

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来源期刊
Translational Medicine of Aging
Translational Medicine of Aging Medicine-Geriatrics and Gerontology
CiteScore
5.30
自引率
0.00%
发文量
2
审稿时长
103 days
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