Efficacia dell’antibiotico-terapia locale in aggiunta alla terapia meccanica non chirurgica parodontale: studio sperimentale split-mouth

Objectives

To assess the effectiveness of local antibiotic therapy with sodium piperacillin plus scaling/root-planing (SRP) versus scaling and root-planing with local application of chlorhexidine for treating periodontal pockets in selected patients with chronic generalized periodontitis.

Materials and methods

We conducted an experimental split-mouth study of 20 patients with chronic generalized periodontitis (probing pocket depth [PPD] ≥5 mm). Each oral cavity was divided into two sectors: the first was treated with SRP plus local application of sodium piperacillin and the second with SRP plus local application of chlorhexidine gel. The PPD and bleeding on probing (BOP) indexes were checked at baseline (time 0) and 1, 3, and 6 months after treatment, and the data obtained were subjected to statistical analysis.

Results

Analysis of PPD and BOP indexes recorded before, during, and after treatment revealed no statistically significant differences between the two therapeutic approaches tested (SRP + sodium piperacillin vs SRP + chlorhexidine).

Conclusions

Within the limits of this study, sodium piperacillin and chlorhexidine appear to be equally effective for use during SRP for the treatment of moderate-severe chronic generalized periodontitis.