sugammadex在烧伤患者中的应用:描述性研究

Eduardo Rodríguez Sánchez M., Concepción Martínez Torres, Pablo Herrera Calo, Ignacio Jiménez
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引用次数: 0

摘要

目的烧伤患者对麻醉医师来说是一个挑战,入院期间需要进行多次手术,并且大多数时候需要全身麻醉和肌肉放松。他们有呼吸系统损伤,对肌肉松弛剂的反应与健康患者不同,因此适当的监测和逆转是至关重要的。我们分析了sugammadex在该人群中的有效性和安全性。材料与方法前瞻性描述性研究4例重度烧伤患者,在全身麻醉和神经肌肉松弛下行巩膜切开术。主要变量为拔管前给药后TOF大于0.9的恢复时间。结果在TOF比大于0.9的烧伤患者中,使用Sugammadex后平均恢复时间为4.95 min, 95% CI (3.25 ~ 6.64, P = 0.53);结论在烧伤患者中,使用Sugammadex恢复神经肌肉松弛是有效且安全的。为了证实这一数据,需要对更大的人口进行更多的分析和比较研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Utilización del sugammadex en el paciente quemado: estudio descriptivo

Objectives

The burn patient is a challenge for the anesthesiologist, undergoing several surgeries during admission, and requiring general anesthesia and muscle relaxation most of the times. They have respiratory system impairment and a response to muscle relaxants that differs from the healthy patient, thus proper monitoring and reversal is crucial. We analyzed sugammadex effectiveness and safety in this population.

Material and methods

Prospectively descriptive study including 4 patients, all of them considered major burn patients, who underwent escharotomy with general anesthesia and neuromuscular relaxation. The main variable was the time for recovery of a TOF higher than 0.9 after the administration of sugammadex before extubation.

Results

Mean time of recovery from a TOF ratio higher than 0.9 following the administration of Sugammadex was of 4.95 min 95% CI (3.25-6.64, P = .53);

Conclusions

the reversion of neuromuscular relaxation with sugammadex appears to be effective and safe in the burn patient. More analytical, comparative studies, of larger populations would be necessary to confirm this data.

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