内生真菌Byssochlamys sp.的两种新呋喃酮衍生物及其细胞毒性活性。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-10-27 DOI:10.1080/14786419.2023.2275269

Jie Wang, Wen-Bin Gao, Fan-Wei Liu, Qi Liu, Bo Song, Jin Ye, Ying Chen, Cai-Lin Zhao, Wei Dong, Li-Na Guo, Bo Song

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引用次数: 0

摘要

从湿地植物芦苇中分离的内生真菌Byssochlamys sp.中纯化了两种新的呋喃酮衍生物，byssochlanones A-B（1-2）。它们的结构是在广泛的光谱分析的基础上阐明的。化合物1-2代表典型的呋喃酮类似物，其在天然产物中不常见。与实验CD相比，化合物1-2的绝对构型通过量子化学电子圆二色性（ECD）计算进行了鉴定。此外，测试了化合物1-2对HCT-8和Hela癌症细胞系的细胞毒性活性，化合物2对HCT-2细胞表现出中等活性，IC50值为21.3 μM。

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Two new furanone derivatives from the endophytic fungus Byssochlamys sp. and their cytotoxic activities.

Two new furanone derivatives, byssochlanones A-B (1-2) were purified from the endophytic fungus Byssochlamys sp. isolated from the wetland plant, Phragmites australis. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compounds 1-2 represented typical furanone analogues which are not common in natural products. The absolute configuration of compounds 1-2 were identified through quantum-chemical electronic circular dichroism (ECD) calculation compared with their experimental CD. In addition, compounds 1-2 were tested for their cytotoxic activities against HCT-8 and Hela cancer cell lines, and compound 2 showed moderate activity against HCT-8 cells with IC₅₀ value of 21.3 μM.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.