在人类实验性牙龈炎模型中,稳定的氟化亚锡洁牙剂对临床、免疫调节和微生物结果的影响。

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Noah Fine, Abdelahhad Barbour, Kamini Kaura, Kristopher A. Kerns, Dandan Chen, Harsh M. Trivedi, Juliana Gomez, Amarpreet Sabharwal, Jeffrey S. McLean, Richard P. Darveau, Michael Glogauer
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引用次数: 0

摘要

背景:氟化亚锡洁牙剂具有良好的临床疗效。在这项研究中,我们评估了氟化亚锡对炎症和口腔微生物组的影响。方法:在这项随机、平行、双盲、对照的临床试验中,我们通过评估磷酸锌稳定的氟化亚锡(试验)和氟化钠(对照)洁牙剂的探针出血、牙龈指数和牙菌斑指数,比较了实验性牙龈炎的临床解决方案。此外,比较了这些组的口腔中性粒细胞计数、中性粒细胞的全身启动、炎症标志物的龈沟液(GCF)表达和口腔微生物组。结果:我们发现,与对照组相比,当参与者在诱发实验性牙龈炎之前使用测试洁牙剂时,测试组在实验性牙髓炎中的探查出血显著减少。试验组还显示,在实验性牙龈炎期间,炎症标志物(基质金属蛋白酶8[MMP8]、核因子κ-β配体受体激活剂[RANKL])、口腔中性粒细胞(PMN)计数和全身中性粒细胞启动(CD11b表达)的GCF水平显著降低。此外,在试验组中,革兰氏阴性属卟啉单胞菌属、单核菌属和密螺旋体属显著减少。结论:磷酸锌稳定的氟化亚锡洁牙剂在临床上减少了牙龈炎症,并对微生物组和免疫标志物产生了有益影响。这种干预措施应被探索为预防牙菌斑诱导的牙龈炎发展为牙周炎的辅助措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of a stabilized stannous fluoride dentifrice on clinical, immunomodulatory, and microbial outcomes in a human experimental gingivitis model

Effects of a stabilized stannous fluoride dentifrice on clinical, immunomodulatory, and microbial outcomes in a human experimental gingivitis model

Background

Stannous fluoride dentifrice is well established for its beneficial clinical effects. In this study, we evaluated the effects of stannous fluoride on inflammation and oral microbiome.

Methods

In this randomized, parallel-arm, double-blind, controlled clinical trial, we compared clinical resolution of experimental gingivitis by evaluating bleeding on probing, gingival index, and plaque index between stannous fluoride stabilized with zinc phosphate (test) and sodium fluoride (control) dentifrices. Further, these groups were compared for oral neutrophil counts, systemic priming of neutrophils, gingival crevicular fluid (GCF) expression of inflammatory markers, and the oral microbiome.

Results

We found significant reduction in bleeding on probing in the test group compared to the control group in experimental gingivitis when participants used the test dentifrice prior to induction of experimental gingivitis. The test group also showed significant reductions in GCF levels of inflammatory markers (matrix metalloproteinase 8 [MMP8], receptor activator of nuclear factor kappa-Β ligand [RANKL]), oral polymorphonuclear neutrophil (PMN) counts, and systemic neutrophil priming (CD11b expression) during experimental gingivitis. Further, significant reductions in the gram-negative genera Porphyromonas, Tannerella, and Treponema were noted in the test group.

Conclusion

The stannous fluoride stabilized with zinc phosphate dentifrice formulation demonstrated clinical reduction in gingival inflammation and a beneficial effect on microbiome and immune markers. This intervention should be explored as a preventive aid in the progression of plaque-induced gingivitis to periodontitis.

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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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