淋巴管内皮细胞对稳定直流电场的淋巴管生成反应。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-10-27 DOI:10.1080/19336918.2023.2271260
Linbo Guan, Ping Fan, Yufeng Wang, Xinghui Liu, Rui Liu, Wandi Ma, Huai Bai
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引用次数: 0

摘要

淋巴血管生成在各种生理和病理条件下发挥着关键作用。已经观察到稳定直流电场(DC-EFs)诱导与血管生成相关的血管内皮行为。本研究探讨了DC-EFs对淋巴管内皮细胞(LECs)淋巴管生成反应的影响。我们证明了EFs刺激诱导培养中人类LECs的定向迁移、重新定向和延伸。这些淋巴管生成反应需要VEGF受体3(VEGFR-3)的激活,并通过与肌动蛋白细胞骨架重组相关的PI3K-Akt、Erk1/2和p38MAPK信号通路介导。我们的研究结果表明,内源性EFs可能在体内淋巴管生成中发挥作用,VEGFR-3信号激活可能参与EFs驱动的LECs的细胞功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lymphangiogenic responses of lymphatic endothelial cells to steady direct-current electric fields.

Lymphangiogenesis plays pivotal roles in diverse physiological and pathological conditions. Steady direct-current electric fields (DC EFs) induce vascular endothelial behaviors related to angiogenesis have been observed. This study investigated the effects of DC EFs on the lymphangiogenic response of lymphatic endothelial cells (LECs). We demonstrated that EFs stimulation induced directional migration, reorientation, and elongation of human LECs in culture. These lymphangiogenic responses required VEGF receptor 3 (VEGFR-3) activation and were mediated through the PI3K-Akt, Erk1/2, and p38 MAPK signaling pathways in relation to the reorganization of the actin cytoskeleton. Our results indicate that endogenous EFs may play a role in lymphangiogenesis in vivo, and VEGFR-3 signaling activation may be involved in the cellular function of LECs driven by EFs.

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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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