Hong-tao Song , Xin-yang Sun , Wei Niu , Qiao-li Zhang , Li-yi Zhang , Ai-fang Zhong
{"title":"miRNA-4485表达水平与重度抑郁症患者抑郁症状严重程度的关系","authors":"Hong-tao Song , Xin-yang Sun , Wei Niu , Qiao-li Zhang , Li-yi Zhang , Ai-fang Zhong","doi":"10.1016/j.ejpsy.2022.09.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and </span>major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.</p></div><div><h3>Methods</h3><p>Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale<span> (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology<span> assessments before and after three weeks of treatment.</span></span></p></div><div><h3>Results</h3><p>The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (<em>P <</em> 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (<em>P <</em> 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (<em>P <</em> 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (<em>P <</em> 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (<em>p <</em> 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (<em>P <</em> 0.05).</p></div><div><h3>Conclusion</h3><p>MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 15-23"},"PeriodicalIF":2.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients\",\"authors\":\"Hong-tao Song , Xin-yang Sun , Wei Niu , Qiao-li Zhang , Li-yi Zhang , Ai-fang Zhong\",\"doi\":\"10.1016/j.ejpsy.2022.09.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and objectives</h3><p><span>Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and </span>major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.</p></div><div><h3>Methods</h3><p>Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale<span> (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology<span> assessments before and after three weeks of treatment.</span></span></p></div><div><h3>Results</h3><p>The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (<em>P <</em> 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (<em>P <</em> 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (<em>P <</em> 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (<em>P <</em> 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (<em>p <</em> 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (<em>P <</em> 0.05).</p></div><div><h3>Conclusion</h3><p>MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.</p></div>\",\"PeriodicalId\":12045,\"journal\":{\"name\":\"European Journal of Psychiatry\",\"volume\":\"37 1\",\"pages\":\"Pages 15-23\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0213616322000805\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213616322000805","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients
Background and objectives
Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.
Methods
Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology assessments before and after three weeks of treatment.
Results
The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (P < 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (P < 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (P < 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (P < 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (p < 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (P < 0.05).
Conclusion
MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.
期刊介绍：
The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
