BACTEC MGIT 960培养诊断为结核的临床标本的组织病理学特征

IF 1.9 Q3 INFECTIOUS DISEASES
Nguyen Kim Cuong , Dang Van Thanh , Dinh Van Luong , Nguyen Manh The , Truong Duc Thai , Anh Tran Thi Tuan , Doan Thu Ha , Vu Quoc Dat
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引用次数: 0

摘要

在肺结核负担高的中低收入国家,肺外结核的诊断仍然具有挑战性。本研究旨在描述确诊结核病患者活检样本的组织学特征。这是对越南国立肺科医院结核分枝杆菌液体培养基培养阳性的临床活检标本和组织病理学检查的回顾性研究。在1045份分枝杆菌培养的活检标本中,培养的结核分枝杆菌的总生长率为20.7%(216/1045)。手术活检标本中MIGT培养的阳性率在骨标本中为75%,其次是脊椎标本(51.3%)和关节标本(26.4%)。细针抽吸标本中,淋巴结和胸膜标本的MIGT培养阳性率分别为26.3%和25.3%。在培养证实为TB的标本中,最常见的组织病理学提示TB的发现是上皮样细胞(83.3%)、Langhans巨细胞(75.9%)、,和干酪样坏死(75.5%)。结核培养物中提示结核的组织学特征在经证实的活检样本中所占比例很高,这支持进一步评估组织学检查,并将其与其他推荐的可疑结核样本的快速分子分析相结合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathological features in the clinical specimens with tuberculosis diagnosis by BACTEC MGIT 960 culture

Diagnosis of extrapulmonary tuberculosis remains challenging in lower-middle income countries with high burden of tuberculosis (TB). This study aims to describe the histological characteristics in biopsy samples from patients with confirmed TB. This is a retrospective study of clinical biopsy specimens with positive liquid medium culture for Mycobacterium tuberculosis and histopathological examination in the National Lung Hospital in Vietnam. Among 1045 biopsy specimens with mycobacteria culture, the overall rate of growth of Mycobacteria tuberculosis in culture was 20.7% (216/1045). The positivity rates of MIGT culture among surgical biopsy specimens were 75% in bone specimen, followed by vertebral specimens (51.3%), and joint specimens (26.4%). For specimens obtained by the fine needle aspiration, the positivity rates of MIGT culture were 26.3% in lymph node and 25.3% in pleural specimen. Among specimens with culture confirmation of TB, the most common histopathoglogical suggestive finding of TB was the presence of epithelioid cell (83.3%), Langhans giant cells (75.9%), and caseous necrosis (75.5%). The high proportion of histological features suggestive of TB among the TB culture confirmed biopsy samples support for further evaluation of histological examination and its combination with other recommended rapid molecular assays in specimens with suspicion of TB.

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来源期刊
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine
CiteScore
4.00
自引率
5.00%
发文量
44
审稿时长
30 weeks
期刊介绍: Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.
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