珊瑚虫毒液的血管舒张活性包括激活NO/cGMP途径和抑制钙流入血管平滑肌细胞

IF 3.6 Q2 TOXICOLOGY
Enrique de Jesus-López , Luis Cuéllar-Balleza , Luis Fernando Díaz-Peña , Francisco Javier Luna-Vázquez , César Ibarra-Alvarado , José Alejandro García-Arredondo
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引用次数: 0

摘要

狼蛛毒液可能是药理学研究中有用的新血管舒张剂成分的天然来源。此外,毒液的生物功能数据对于增强对这些物种的生物多样性和进化的了解非常重要。本研究旨在描述蛇床子毒液对离体大鼠主动脉环的血管舒张活性。这种毒液诱导的血管舒张活性在与L-NAME或ODQ孵育后显著降低。对大鼠主动脉匀浆中亚硝酸盐浓度的测量表明,毒液显著提高了基础水平。此外,毒液可以减弱钙引起的收缩。这些结果表明,P.ornata毒液含有血管舒张剂成分的混合物,这些成分通过激活一氧化氮/cGMP途径以及通过涉及钙流入血管平滑肌细胞的内皮非依赖性机制发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Vasodilator activity of Poecilotheria ornata venom involves activation of the NO/cGMP pathway and inhibition of calcium influx to vascular smooth muscle cells

Vasodilator activity of Poecilotheria ornata venom involves activation of the NO/cGMP pathway and inhibition of calcium influx to vascular smooth muscle cells

Tarantula venoms may be a natural source of new vasodilator components useful in pharmacological research. Moreover, biological function data of the venoms are important to enhance the knowledge about the biodiversity and evolution of these species. The present study aims to describe the vasodilatory activity induced by the venom of Poecilotheria ornata on isolated rat aortic rings. This venom induced a vasodilator activity that was significantly reduced after incubation with L-NAME or ODQ. Measurements of nitrite concentrations on rat aorta homogenates showed that the venom significantly increased the basal levels. Moreover, the venom attenuates the contraction induced by calcium. These results suggest that P. ornata venom contains a mixture of vasodilator components that act through the activation of the nitric oxide/cGMP pathway, as well as, through an endothelium-independent mechanism that involves the calcium influx into vascular smooth muscle cells.

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来源期刊
Toxicon: X
Toxicon: X Pharmacology, Toxicology and Pharmaceutics-Toxicology
CiteScore
6.50
自引率
0.00%
发文量
33
审稿时长
14 weeks
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