了解睾丸特异性蛋白质组中与年龄相关的变化。

IF 3.8 3区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS
Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-12-30 DOI:10.1080/14789450.2023.2274857
Ana D Martins, João C Ribeiro, Rita Ferreira, Marco G Alves, Pedro F Oliveira
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引用次数: 0

摘要

引言:发展中国家的生育率在过去几十年中有所下降,随着社会的发展,延迟生育的趋势正在上升。随着年龄的增长,男性生育率下降的原因仍然很神秘,这使其成为进一步研究的一个引人注目的关键领域。然而,致力于解开这一谜团的研究数量有限,这是一个挑战。因此,我们的目的是阐明男性睾丸在衰老过程中的一些上调和下调机制。涵盖的领域:在此,我们对衰老过程中睾丸蛋白质组变化的研究进行了批判性概述,从性成熟的年轻男性到预期寿命结束的老年男性。还讨论了有生精障碍和无生精障碍男性睾丸蛋白质组图谱的比较研究,并重点介绍了涉及的关键蛋白质和途径。专家意见:进行年龄比较研究的困难,特别是对老年研究对象的比较研究,使这一研究课题具有相当的挑战性。另一个值得一提的话题是睾丸组织的异质性和庞大的细胞组成,这使得蛋白质组数据的解释变得棘手。研究对象睾丸组织中的细胞类型分类和合并症测试将有助于缓解这些问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding the age-related alterations in the testis-specific proteome.

Introduction: Fertility rates in developing countries have declined over the past decades, and the trend of delayed fatherhood is rising as societies develop. The reasons behind the decline in male fertility with advancing age remain mysterious, making it a compelling and crucial area for further research. However, the limited number of studies dedicated to unraveling this enigma poses a challenge. Thus, our objective is to illuminate some of the upregulated and downregulated mechanisms in the male testis during the aging process.

Areas covered: Herein, we present a critical overview of the studies addressing the alterations of testicular proteome through the aging process, starting from sexually matured young males to end-of-life-expectancy aged males. The comparative studies of the proteomic testicular profile of men with and without spermatogenic impairment are also discussed and key proteins and pathways involved are highlighted.

Expert opinion: The difficulty of making age-comparative studies, especially of advanced-age study subjects, makes this topic of study quite challenging. Another topic worth mentioning is the heterogeneous nature and vast cellular composition of testicular tissue, which makes proteome data interpretation tricky. The cell type sorting and comorbidities testing in the testicular tissue of the studied subjects would help mitigate these problems.

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来源期刊
Expert Review of Proteomics
Expert Review of Proteomics 生物-生化研究方法
CiteScore
7.60
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.
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