糖蛋白质组学对肝细胞癌研究的贡献:2023年更新。

IF 3.8 3区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS
Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-10-27 DOI:10.1080/14789450.2023.2265064
Yingqi Zheng, Ke Gao, Qiang Gao, Shu Zhang
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引用次数: 0

摘要

简介:肝细胞癌(HCC)在全球范围内是一个重要的负担,在最常见的诊断癌症中排名第六,是癌症相关死亡率的第三大原因。糖蛋白质组学作为蛋白质组学的一个重要分支,在HCC研究领域已经取得了重大成果。异常蛋白糖基化已显示出通过调节广泛的肿瘤促进信号通路来促进肝细胞的恶性转化。糖蛋白质组为了解癌症进展、肿瘤免疫和临床结果提供了有价值的信息,可作为HCC的潜在诊断、预后和治疗工具,综述了糖蛋白质组学的最新进展,对HCC的临床应用(诊断和预后)和分子机制(肝癌的发生、进展、干性和复发以及耐药性)做出了贡献。专家意见:糖蛋白质组学在HCC中显示出前景,可以增强早期检测、风险分层和个性化治疗。挑战包括样本异质性、不同的聚糖结构、敏感性问题、复杂的工作流程、有限的数据库以及对免疫细胞糖基化的不完全理解。解决这些限制需要合作、技术进步、标准化和验证研究。未来的研究应该集中在靶向异常蛋白质糖基化的治疗上。糖生物标志物和糖基化靶向治疗的进展将极大地影响HCC的诊断、预后和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glycoproteomic contributions to hepatocellular carcinoma research: a 2023 update.

Introduction: Hepatocellular carcinoma (HCC) represents a significant burden globally, which ranks sixth among the most frequently diagnosed cancers and stands as the third leading cause of cancer-related mortality. Glycoproteomics, as an important branch of proteomics, has already made significant achievements in the field of HCC research. Aberrant protein glycosylation has shown to promote the malignant transformation of hepatocytes by modulating a wide range of tumor-promoting signaling pathways. The glycoproteome provides valuable information for understanding cancer progression, tumor immunity, and clinical outcome, which could serve as potential diagnostic, prognostic, and therapeutic tools in HCC.

Areas covered: In this review, recent advances of glycoproteomics contribute to clinical applications (diagnosis and prognosis) and molecular mechanisms (hepatocarcinogenesis, progression, stemness and recurrence, and drug resistance) of HCC are summarized.

Expert opinion: Glycoproteomics shows promise in HCC, enhancing early detection, risk stratification, and personalized treatments. Challenges include sample heterogeneity, diverse glycans structures, sensitivity issues, complex workflows, limited databases, and incomplete understanding of immune cell glycosylation. Addressing these limitations requires collaborative efforts, technological advancements, standardization, and validation studies. Future research should focus on targeting abnormal protein glycosylation therapeutically. Advancements in glycobiomarkers and glycosylation-targeted therapies will greatly impact HCC diagnosis, prognosis, and treatment.

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来源期刊
Expert Review of Proteomics
Expert Review of Proteomics 生物-生化研究方法
CiteScore
7.60
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.
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