口腔鳞状细胞癌的临床病理特征,以从不吸烟和不喝酒的患者为中心。

IF 1 Q3 OTORHINOLARYNGOLOGY
International Archives of Otorhinolaryngology Pub Date : 2023-10-23 eCollection Date: 2023-10-01 DOI:10.1055/s-0042-1755433
Yoshiyuki Iida, Shinichi Okada, Yuki Irifune, Seiya Goto, Kotaro Ishida, Fuyuki Sato, Takashi Yurikusa, Koiku Asakura, Ayaka Tsuzuki, Takashi Mukaigawa
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引用次数: 0

摘要

介绍 据报道,在从不吸烟和饮酒的患者中,口腔癌占很大比例。然而,这一比例可能因子网站和种族而异。客观的 我们旨在确定日本人群中口腔鳞状细胞癌(SCC)的临床病理特征。方法 我们回顾性分析了2002年9月至2015年11月在我院诊断为口腔鳞状细胞癌的患者的记录。我们回顾了患者的性别、年龄、肿瘤状况、治疗、吸烟、饮酒、多种原发性癌症和预后。计算总体和病因特异性生存率,并通过单变量分析评估临床病理变量的影响。此外,还对死亡原因进行了评估。后果 在纳入本研究的63名患者(男性:38名;女性:25名)中,29名(46.0%)从未吸烟或饮酒。女性几乎比男性大5岁(p = 0.014)。该组从不吸烟或饮酒的女性人数不成比例地高于吸烟者或饮酒者(p 结论 我们的研究证实,口腔鳞状细胞癌可能在日本老年患者中发展,尤其是从未吸烟或饮酒的女性。这些患者可能有第二原发性恶性肿瘤的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinicopathological Features of Buccal Squamous Cell Carcinoma with Focus on Patients Who Never Smoke and Never Drink.

Introduction  Oral carcinoma has been reported at a substantial proportion in patients who never smoke and never drink. However, the proportion may vary by subsite and ethnicity. Objective  We aimed to determine the clinicopathological features of buccal squamous cell carcinoma (SCC) in a Japanese population. Methods  We retrospectively analyzed the records of patients diagnosed with buccal SCC at our institution from September 2002 to November 2015. We reviewed the gender, age, tumor status, treatment, smoking, alcohol drinking, multiple primary cancers, and prognosis of the patients. The overall and cause-specific survival rates were calculated, and the effects of clinicopathological variables were assessed by univariate analysis. Furthermore, the cause of death was evaluated. Results  Among the 63 patients (men: 38; women: 25) included in the present study, 29 (46.0%) never smoked or drank. Women were almost 5 years older than men ( p  = 0.014). The number of women in the group who never smoked or drank was disproportionately higher than that of those in the smoker or drinker groups ( p  < 0.001). In total, 29 patients (46.0%) had 59 multiple primary cancers, including 26 oral cancers. Surgeries and radiotherapy were performed in 57 (90.5%) and 6 (9.5%) cases, respectively. The 5-year overall survival and disease-specific survival rates were 74.6 and 78.8%, respectively. Conclusion  Our study confirms that buccal SCC may develop in older adult Japanese patients, especially in women who have never smoked or drank. These patients could be at risk for second primary malignancy.

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来源期刊
CiteScore
2.80
自引率
0.00%
发文量
84
审稿时长
12 weeks
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