MicroRNA响应性DNA树状结构作为智能STING信号放大器（Adv.Therap.10/2023）

IF 3.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Advanced Therapeutics Pub Date : 2023-10-19 DOI:10.1002/adtp.202370028

Rong Wu, Yi Xue, Jiayin Zhan, Zhiyuan Feng, Jun-Jie Zhu, Jingjing Zhang

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引用次数: 0

摘要

受蜘蛛编织网捕捉蝴蝶的启发，封面展示了一种微小的RNA响应DNA树状大分子系统，该系统可以选择性地捕获cGAS蛋白，有效激活cGAS-STING通路，并刺激强大的树突细胞成熟，以增强癌症免疫疗法。本文由吴蓉、薛毅、詹佳音、冯志远、朱俊杰和张晶晶报道，文章编号2300088。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

MicroRNA-Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier (Adv. Therap. 10/2023)

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MicroRNA-Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier (Adv. Therap. 10/2023)

Inspired by spiders weaving webs to catch butterflies, the cover presents a microRNA-responsive DNA dendrimer system that can selectively capture cGAS protein, effectively activate cGAS-STING pathway, and stimulate potent dendritic cells maturation for enhanced cancer immunotherapy. This is reported by Rong Wu, Yi Xue, Jiayin Zhan, Zhiyuan Feng, Jun-Jie Zhu, and Jingjing Zhang in article number 2300088.

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来源期刊

Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.10

自引率

2.20%

发文量

130