用于靶向荧光成像和疾病治疗的生物修饰或仿生聚合物点综述

iRadiology Pub Date : 2023-07-15 DOI:10.1002/ird3.26
Jintong Guo, Meng Du, Zhiyi Chen, Xueli Chen, Zhen Yuan
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引用次数: 1

摘要

由于其固有的可调谐光谱、高亮度、优异的生物稳定性和生物相容性以及表面的功能化,半导体聚合物点(Pdots)现在通过与肽或仿生材料的生物偶联在荧光(FL)成像和疾病治疗中发挥着重要作用。特别是,仿生Pdots在病变的靶向成像中表现出其能力,并提高了靶向疾病治疗的疗效。这篇综述将考察用于增强疾病检测和治疗的生物修饰和仿生Pdots的设计和功能化策略的最新进展。更重要的是,这两种修饰在靶向FL成像和癌症治疗中的应用有待详细讨论。同时,还讨论了仿生和生物修饰Pdots的主要挑战和前景,这将为改进疾病检测和成像引导治疗开辟新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A review of biomodified or biomimetic polymer dots for targeted fluorescent imaging and disease treatments

A review of biomodified or biomimetic polymer dots for targeted fluorescent imaging and disease treatments

Due to their inherent tunable spectrum, high brightness, excellent biostability and biocompatibility, and functionalization of surfaces, semiconducting polymer dots (Pdots) are now playing an essential role in fluorescent (FL) imaging and disease treatment through bioconjugation with peptides or biomimetic materials. In particular, biomimetic Pdots exhibit their capability in targeted imaging of lesion and increased efficacy for targeting disease treatment. This review will inspect the recent advances in the design and functionalization strategies of biomodified and biomimetic Pdots for enhanced disease detection and therapy. More importantly, the application of these two modifications in targeted FL imaging and cancer treatment is to be addressed in detail. Meanwhile, the main challenges and prospects of biomimetic and biomodified Pdots are to be discussed, which will pave a new avenue for improved disease detection and imaging-guided treatment.

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