Optofluidic identification of single microorganisms using fiber-optical-tweezer-based Raman spectroscopy with artificial neural network (BMEMat 1/2023)

Pathogenic microorganisms that cause diseases are like the hateful monsters in Journey to the West. With strong mobility, they keep wandering everywhere, making it very difficult to identify them in a great variety of species using conventional microscopes. In article number 10.1002/bmm2.12007, Y. Zhang et al. develop an optofluidic method for identifying single microorganisms in microfluidic channels using fiber-optical-tweezer-based Raman spectroscopy with artificial neural network. Such a method is just like Sun Wukong (also called the Great Sage Equalling Heaven in the same fiction) who owns the super power of “Immobilization Spell” that traps the pathogenic microorganisms and “Piercing Eyes” that rapidly and accurately identify the microbial species.