氰基和水产养殖用氯酸盐的加合物

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

JBIC Journal of Biological Inorganic Chemistry Pub Date : 2023-07-26 DOI:10.1007/s00775-023-02015-z

Maria Lehene, Adrian M. V. Brânzanic, Radu Silaghi-Dumitrescu

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引用次数: 0

摘要

已知次氯酸盐氧化降解钴胺素的corrin环。在这里，瞬态反应中间体描述了水的反应，以及氰钴胺素与次氯酸盐的反应，使用停流紫外可见动力学。对于水钴胺素，中间体是由次氯酸盐取代水配体产生的。对于氰钴胺素，中间体是由苯并咪唑配体反式取代氰化物而产生的。在这两种情况下，中间产物都有一个新的Co(III)-OCl−键，这也得到了密度泛函理论(DFT)计算的支持。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The adducts of cyano- and aquacobalamin with hypochlorite

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The adducts of cyano- and aquacobalamin with hypochlorite

Hypochlorite is known to oxidatively degrade the corrin ring of cobalamin. Here, transient reaction intermediates are described in the reaction of aqua as well as of cyano-cobalamin with hypochlorite, using stopped-flow UV–vis kinetics. For aqua-cobalamin, the intermediate is assigned as arising from substitution of the aqua ligand with hypochlorite. For cyano-cobalamin, the intermediate is proposed to arise from substitution of the benzimidazole ligand trans to the cyanide. In both cases, the intermediates would feature a new Co(III)-OCl⁻bond—which is also supported by density functional theory (DFT) calculations.

Graphical abstract

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来源期刊

JBIC Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.