一种无催化剂、绿色高效的超声辅助合成亚甲基异恶唑-5(4H)-的方法

Q3 Materials Science

JCIS open Pub Date : 2023-10-17 DOI:10.1016/j.jciso.2023.100097

Jyothi Bankuru , Venkateswara Rao Battula , S. Tirumala Santhoshkumar , Sidama Gopal , Ram Pratap Meena , N. Zaheer Ahmed

{"title":"一种无催化剂、绿色高效的超声辅助合成亚甲基异恶唑-5(4H)-的方法","authors":"Jyothi Bankuru , Venkateswara Rao Battula , S. Tirumala Santhoshkumar , Sidama Gopal , Ram Pratap Meena , N. Zaheer Ahmed","doi":"10.1016/j.jciso.2023.100097","DOIUrl":null,"url":null,"abstract":"<div><p>A catalyst-free, green and efficient protocol for the one-pot, multi-component, synthesis of Methyleneisoxazole-5(4H)-ones (4a-l) from the reaction of Ethyl acetoacetate, aromatic aldehyde, and hydroxylamine hydrochloride in ethanol as green solvent under ultrasound irradiation at ambient temperature is described. This protocol offers several positive benefits, including simple handling, rapid reaction time period (≤10 mints), easy workup process, waste-free, gentler reaction conditions, ecologically friendly, cleaner reaction, absence of any a laborious purification and excellent yields.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"12 ","pages":"Article 100097"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A catalyst-free, green and efficient protocol for the synthesis of methyleneisoxazole-5(4H)-ones supported by ultrasonic irradiation\",\"authors\":\"Jyothi Bankuru , Venkateswara Rao Battula , S. Tirumala Santhoshkumar , Sidama Gopal , Ram Pratap Meena , N. Zaheer Ahmed\",\"doi\":\"10.1016/j.jciso.2023.100097\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A catalyst-free, green and efficient protocol for the one-pot, multi-component, synthesis of Methyleneisoxazole-5(4H)-ones (4a-l) from the reaction of Ethyl acetoacetate, aromatic aldehyde, and hydroxylamine hydrochloride in ethanol as green solvent under ultrasound irradiation at ambient temperature is described. This protocol offers several positive benefits, including simple handling, rapid reaction time period (≤10 mints), easy workup process, waste-free, gentler reaction conditions, ecologically friendly, cleaner reaction, absence of any a laborious purification and excellent yields.</p></div>\",\"PeriodicalId\":73541,\"journal\":{\"name\":\"JCIS open\",\"volume\":\"12 \",\"pages\":\"Article 100097\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JCIS open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666934X23000247\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Materials Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JCIS open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666934X23000247","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Materials Science","Score":null,"Total":0}

引用次数: 0

摘要

介绍了一种无催化剂、绿色高效的以乙醇为绿色溶剂，以乙酰乙酸乙酯、芳香醛和盐酸羟胺为原料，在室温超声照射下，一锅多组分合成亚甲二恶唑-5(4H)- 1 (4a- 1)的方法。该方案具有几个积极的优点，包括简单的处理，快速的反应时间(≤10分钟)，容易的后处理过程，无废物，温和的反应条件，生态友好，更清洁的反应，没有任何费力的纯化和优异的产量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A catalyst-free, green and efficient protocol for the synthesis of methyleneisoxazole-5(4H)-ones supported by ultrasonic irradiation

查看原文本刊更多论文

A catalyst-free, green and efficient protocol for the synthesis of methyleneisoxazole-5(4H)-ones supported by ultrasonic irradiation

A catalyst-free, green and efficient protocol for the one-pot, multi-component, synthesis of Methyleneisoxazole-5(4H)-ones (4a-l) from the reaction of Ethyl acetoacetate, aromatic aldehyde, and hydroxylamine hydrochloride in ethanol as green solvent under ultrasound irradiation at ambient temperature is described. This protocol offers several positive benefits, including simple handling, rapid reaction time period (≤10 mints), easy workup process, waste-free, gentler reaction conditions, ecologically friendly, cleaner reaction, absence of any a laborious purification and excellent yields.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

JCIS open Physical and Theoretical Chemistry, Colloid and Surface Chemistry, Surfaces, Coatings and Films

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

36 days