社区居住的老年人高尿酸血症和代谢受损:贝叶斯方法

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Rafael da Silva Passos , Mauro Fernandes Teles , Ícaro JS. Ribeiro , Ivna Vidal Freire , Ramon Alves Pires , Ludmila Schettino , Alinne Alves Oliveira , VVerônica Porto de Freitas , Cezar Augusto Casotti , Rafael Pereira
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引用次数: 0

摘要

血清尿酸(UA)水平已成为几种病理过程的候选生物标志物,尤其是心脏代谢疾病。目的本研究旨在比较UA正常和高水平的社区老年人心脏代谢功能障碍的生物标志物。进行静脉抽血并用于获得UA、甘油三酯和葡萄糖水平。进行人体测量以记录身高、体重和腰围。根据血清和人体测量参数,计算甘油三酯/葡萄糖指数(TyG)、脂质积累产物(LAP)和内脏脂肪指数(VAI)。线性混合模型分析用于确定心脏代谢参数(VAI、LAP和TyG)的组间差异,以组为固定因素,性别、低血糖和低脂药物的使用为随机因素。贝叶斯分析是为了检验证据的大小。结果具有高血清UA的社区老年人表现出统计学上更高的TyG值(p<0.05)(平均差异=0.24[95%CI=0.39-0.90]),VAI(平均差值=0.75[95%CI=0.25至1.25])和LAP(平均差值=15.56[95%CI=3.98至27.15])。贝叶斯分析表明,中等至较强的后验概率有利于替代假设。结论我们的研究结果阐明了社区老年人高尿酸血症状态与脂肪细胞功能障碍、异位脂质沉积和胰岛素抵抗之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyperuricemia and impaired metabolic profile in community-dwelling older adults: A Bayesian approach

Serum uric acid (UA) levels have stood out as a candidate for biomarker of several pathological processes, especially from cardiometabolic diseases.

Purpose

This study aimed to compare biomarkers of cardiometabolic dysfunction in community-dwelling older adults with normal and high levels of UA.

Methods

Cross-sectional study including 228 community-dwelling older adults, clinically stratified as with or without hyperuricemia, according the cutoff point of serum uric acid ≥6 mg/dL for women and ≥7 mg/dL for men. Venous blood withdrawal was conducted and used to obtain UA, triglycerides, and glucose levels. Anthropometric measurements were conducted to record height, body mass, and waist circumference. From serum and anthropometric parameters, triglyceride/glucose index (TyG), lipid accumulation product (LAP), and visceral adiposity index (VAI) were calculated. Linear mixed model analysis was used to determine between-group differences in cardiometabolic parameters (VAI, LAP, and TyG), taking groups as fixed factor and sex, use of hypoglycemiant and hypolipemiant medications as random factors. The Bayesian analysis was conducted to check the magnitude of the evidence.

Results

The community-dwelling older adults with high serum UA exhibited statistically higher values (p < 0.05) of TyG (mean difference = 0.24 [95% CI = 0.39 to 0.90]), VAI (mean difference = 0.75 [95% CI = 0.25 to 1.25]) and LAP (mean difference = 15.56 [95% CI = 3.98 to 27.15]). The Bayesian analysis indicated moderate to strong posterior probabilities favoring the alternative hypothesis.

Conclusion

Our results shed light on the relationship between hyperuricemic state in community-dwelling older adults and adipocyte dysfunction, ectopic lipid deposition, and insulin resistance.

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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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