Manejo conservador con radioterapia e inmunoquimioterapia en el linfoma difuso de células B grandes primario de cuello uterino: Diagnóstico y tratamiento de una entidad rara

Introduction

Primary malignant cervical lymphoma is a very rare disease, which represents only 0.008% of all cervical tumors and 2% of all female extranodal lymphomas.

Main symptoms and/or clinical findings

The case of a 66-year-old woman from the Peruvian Andes is presented, with a disease period of 4 months characterized by gynaecorrhagia, with evidence of a 5 cm tumor cervix. Immunohistochemistry was performed on the biopsy of cervix to differentiate lymphoma from squamous cell carcinoma.

Primary diagnosis

Primary diffuse large B-cell lymphoma of the cervix with Ann Arbor IE IPI low-risk staging.

Therapeutic interventions and results

She being managed with immunochemotherapy (rituximab, cyclophosphamide, adriamycin, vincristine and prednisone), followed by consolidative external radiotherapy at a dose of 3,000 cGy in 15 sessions with a special IMRT technique. Resulting in satisfactory disease control and no complications from irradiation.

Conclusion

Primary diffuse large B-cell lymphoma of the cervix is very rare, therefore, in a case of primary stromal lesion of the cervix, suspicion of lymphoma should be taken into account.