叶状天疱疮流行区携带抗粘粒蛋白1抗体的健康受试者的皮肤超微结构改变:一个病例系列

IF 4.7 Q2 IMMUNOLOGY
Willy Ramos , Nancy Rojas , Alex G. Ortega-Loayza , Mercedes Tello , Gerardo Jiménez , Nicolás Cuba-Cáceres , Gerardo Ronceros , Jhony A. De La Cruz-Vargas , Víctor Juan Vera-Ponce , Nadia Guerrero , Ericson L. Gutierrez
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引用次数: 0

摘要

背景:流行性叶状天疱疮和地方性寻常型天疱疮是秘鲁亚马逊地区特有的自身免疫性皮肤病。目的观察秘鲁亚马逊地区叶状天疱疮和寻常型天疱疮流行区3名健康人的皮肤超微结构变化。患者与方法对3例秘鲁临床健康患者进行病例系列研究,这些患者抗DSG-1抗体呈阳性。本研究包括对先前研究中收集的数据的子分析。结果3例临床健康患者皮肤活检均显示抗粘粒蛋白1 (DSG-1)抗体阳性。高分辨率光学显微镜(HROM)显示棘皮没有溶解。透射电镜(TEM)显示,角质形成细胞间的细胞间隙变宽,细胞间隙中存在颗粒状物质的空泡,细胞质空泡化,桥粒结构丧失,张力丝间的正态分布丧失,基底层细胞间的侧向分离。根据我们的研究结果,健康受试者的抗粘粒蛋白1抗体可以发生超微结构改变,这种改变在透射电子显微镜下可见,而在常规光学显微镜下却看不见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series

Background

Endemic pemphigus foliaceus and endemic pemphigus vulgaris are autoimmune dermatologic disorders endemic to the Peruvian Amazon.

Objective

To determine the ultrastructural skin alterations of three healthy subjects with anti DSG-1 antibodies in areas endemic to pemphigus foliaceus and pemphigus vulgaris in the Peruvian Amazon.

Patients and methods

Case series carried out from data of three clinically healthy subjects positive to anti DSG-1 antibodies, from Peru. This study consists of a sub-analysis of data gathered in a previous study.

Results

Ultrastructural results are presented from the skin biopsies of three clinically healthy patients positive to anti-desmoglein 1 (DSG-1) antibodies. High Resolution Optical Microscopy (HROM) showed the absence of acantholysis. Transmission Electron Microscopy (TEM) showed the widening of intercellular space between keratinocytes, the presence of vacuoles in intercellular space with granular material and cytoplasmic vacuolization, loss of desmosome structure, loss of normal distribution among tonofilaments and lateral separation among cells in the stratum basale.

Conclusion

According to our results, healthy subjects that present anti-desmoglein 1 antibodies can develop ultrastructural alterations that are visible through transmission electron microscopy but not through conventional optical microscopy.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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