一名原子弹爆炸幸存者口腔中发生浆母细胞淋巴瘤

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
Mitsunobu Otsuru , Tomofumi Naruse , Keisuke Omori , Taro Miyoshi , Naoki Katase , Shuichi Fujita , Masahiro Umeda
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引用次数: 0

摘要

浆细胞性淋巴瘤(PBL)是一种不常见但具有侵袭性的弥漫性大B细胞淋巴瘤亚型,其特征是浆细胞分化。它是一种罕见的肿瘤,已知最常发生在因人类免疫缺陷病毒(HIV)或EB病毒(EBV)而处于免疫功能低下状态的人身上。在这里,我们报告了一例PBL病例,该病例发生在一名76岁的长崎原子弹爆炸幸存者身上,他在3岁时暴露在外,没有感染艾滋病毒或EB病毒的证据。患者因口腔肿块就诊于我院。他被诊断为PBL,并接受EPOCH化疗(依托泊苷、泼尼松、长春新碱、环磷酰胺和阿霉素)。3年后未观察到复发。在这种情况下,不能排除原子弹辐射暴露对PBL发展产生影响的可能性。然而,流行病学研究无法证明这一假设,因为只有有限数量的人是原子弹爆炸的幸存者。据我们所知,这是第一份没有证据表明免疫功能受损的原子弹幸存者PBL报告。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Occurrence of plasmablastic lymphoma in the oral cavity of an atomic blast survivor

Plasmablastic lymphoma (PBL) is an uncommon but aggressive subtype of diffuse, large, B-cell lymphoma characterized by plasmablastic differentiation. It is a rare tumor and is known to occur most often in individuals with an immunocompromised state due to human immunodeficiency virus (HIV) or Epstein–Barr virus (EBV).

Here we report a case of PBL with no evidence of HIV or EBV infection in a 76-year-old survivor of the Nagasaki atomic bombings who was exposed at the age of 3 years. The patient presented to our hospital with a complaint of an oral mass. He was diagnosed with PBL and treated with EPOCH chemotherapy (etoposide, prednisolone, vincristine, cyclophosphamide, and doxorubicin). No recurrence was observed after 3 years. The possibility of an effect of atomic bomb radiation exposure on the development of PBL cannot be ruled out in this case. However, epidemiological studies cannot prove this hypothesis because only a limited number of individuals are survivors of atomic bombings. To the best of our knowledge, this is the first report of PBL in an atomic bomb survivor with no evidence of an immunocompromised state.

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CiteScore
0.80
自引率
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129
审稿时长
83 days
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