Nihay Laham-Karam , Isidore Mushimiyimana , Krista Hokkanen , Seppo Ylä-Herttuala
{"title":"非编码RNA在生理和病理血管生成中的作用","authors":"Nihay Laham-Karam , Isidore Mushimiyimana , Krista Hokkanen , Seppo Ylä-Herttuala","doi":"10.1016/j.cophys.2023.100690","DOIUrl":null,"url":null,"abstract":"<div><p>Angiogenesis, the process of building new vessels, is important in physiology. In addition, it is involved in different pathologies, including cancers, ischemia, macular degeneration and inflammatory bowel disease. The regulation of angiogenesis is multifaceted and according to recent data includes transcriptional modulation by enhancers and non-coding RNAs as well as post-transcriptional regulation by microRNAs. In this review, we highlight recent findings in this field that relate both to physiological and pathological angiogenesis and discuss the effects on key angiogenic factors.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Role of non-coding RNAs in physiological and pathological angiogenesis\",\"authors\":\"Nihay Laham-Karam , Isidore Mushimiyimana , Krista Hokkanen , Seppo Ylä-Herttuala\",\"doi\":\"10.1016/j.cophys.2023.100690\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Angiogenesis, the process of building new vessels, is important in physiology. In addition, it is involved in different pathologies, including cancers, ischemia, macular degeneration and inflammatory bowel disease. The regulation of angiogenesis is multifaceted and according to recent data includes transcriptional modulation by enhancers and non-coding RNAs as well as post-transcriptional regulation by microRNAs. In this review, we highlight recent findings in this field that relate both to physiological and pathological angiogenesis and discuss the effects on key angiogenic factors.</p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867323000603\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867323000603","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Role of non-coding RNAs in physiological and pathological angiogenesis
Angiogenesis, the process of building new vessels, is important in physiology. In addition, it is involved in different pathologies, including cancers, ischemia, macular degeneration and inflammatory bowel disease. The regulation of angiogenesis is multifaceted and according to recent data includes transcriptional modulation by enhancers and non-coding RNAs as well as post-transcriptional regulation by microRNAs. In this review, we highlight recent findings in this field that relate both to physiological and pathological angiogenesis and discuss the effects on key angiogenic factors.