少转移性鼻咽癌的手术治疗

Wendan Gong , Shixing Zheng , Hongmeng Yu , Zhe Zhang
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引用次数: 0

摘要

寡转移导向治疗已显示出改善患者预后的前景。在这篇综述中,我们总结了目前对少转移性鼻咽癌(NPC)的理解以及手术在其治疗中的作用。由于大多数支持手术治疗少转移性NPC的临床证据来自非对照、单臂、观察性研究,因此,应谨慎解读之前报道的研究结果,确定合适的少转移切除患者以确保患者的安全性和有效性至关重要。未来研究少转移状态的研究应该采用更稳健的研究设计,如随机对照试验,以指导临床决策。此外,全面了解与少转移性NPC相关的肿瘤生物学对于制定有效的患者治疗策略是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surgical treatment of oligometastatic nasopharyngeal carcinoma

Oligometastasis-directed therapies have shown promise in improving patient outcomes. In this review, we summarized the current understanding of oligometastatic nasopharyngeal carcinoma (NPC) and the role of surgery in its management. Since the majority of clinical evidence supporting the benefit of surgical treatment on oligometastatic NPC is derived from non-controlled, single-arm, observational studies, therefore, findings reported before should be interpreted with caution and it is crucial to identify the right patients for oligometastasectomy to ensure the safety and effectiveness for patients. Future studies investigating the oligometastatic state should employ more robust study designs, such as randomized controlled trials, to guide clinical decision-making. Additionally, a comprehensive understanding of the tumor biology associated with oligometastatic NPC is necessary for developing effective treatment strategies for patients.

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