微波辅助铜催化亚硫酸钠和胺合成磺胺类药物

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI:10.1080/10426507.2023.2198714

Anil Nikam , Jagannath Jadhav , Sagar Sankpal

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引用次数: 0

摘要

在微波辐射下，建立了一种在乙腈：水中进行胺单磺酰化反应的有效方法。在该反应中，等摩尔量的胺和亚磺酸钠在CuBr2的存在下反应，并且省略了氧化剂、配体、添加剂和碱的使用。所开发的方法在短的反应时间内以优异的产率将大量空间和电子上不同的亚磺酸盐和胺转化为相应的磺酰胺。微波和水介质的使用使该方案在开发合成磺酰胺的绿色策略方面具有潜在的用处。

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Microwave assisted, Cu-catalyzed synthesis of sulfonamides using sodium sulfinates and amines

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Microwave assisted, Cu-catalyzed synthesis of sulfonamides using sodium sulfinates and amines

An efficient procedure has been developed under microwave irradiation for the monosulfonylation of amines in acetonitrile:water. In this reaction, equimolar quantities of amines and sodium sulfinates were reacted in presence of CuBr₂ and omitted the use of oxidants, ligands, additives, and bases. The developed methodology converts a wide array of sterically and electronically diverse sulfinate and amines into the corresponding sulfonamides in excellent yields within a short reaction time. The use of microwave and aqueous media makes this protocol potentially useful in the development of a green strategy for the synthesis of sulfonamides.

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.