肉眼可识别的比率H2S探针及其在细胞成像中的应用

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI:10.1080/10426507.2023.2199995

Fangfang Luo , Le Wang , Xiao Zhang , Ping Xu , Xiao Wang , Yi Qu

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引用次数: 0

摘要

制备了一种基于1,8-萘酰亚胺的比率双模式探针NI-SH用于H2S检测。当用H2S处理时，NI-SH的荧光由蓝色（456 nm）变为绿色（540 nm）并且显示肉眼可见的显著的颜色变化（无色到黄色）。进一步的研究表明，NI-SH具有高灵敏度、高选择性和低检测限，约为0.2 μM，并且具有大的斯托克斯位移（84 nm）。通过分析分子轨道的分布，进一步研究了NI-SH的分子间电荷转移（ICT）响应机制。此外，NI-SH在活的Hela细胞中表现出比率荧光反应。

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Ratiometric H2S probe that can be recognized by the naked eye and its application in cell imaging

A ratiometric dual-mode probe NI-SH based on 1,8-Naphthalimide was prepared for H₂S detection. When treated with H₂S, the fluorescence of NI-SH changes from blue (456 nm) to green (540 nm), and displays significant color variation (colorless to yellow) that can visible to the naked eye. Further investigation shows that the NI-SH has high sensitivity, selectivity, and low detection limit at about 0.2 μM, and with large Stokes shift (84 nm). The intermolecular charge transfer (ICT) response mechanism of NI-SH was further studied by analyzing the distributions of the molecular orbital. Besides, NI-SH exhibits a ratiometric fluorescence response in living Hela cells.

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.