利培酮对首发精神分裂症患者血浆血管内皮生长因子水平的影响:初步研究

Psychiatry research communications Pub Date : 2023-09-22 DOI:10.1016/j.psycom.2023.100145

Reiji Yoshimura, Naomichi Okamoto, Gaku Hayasaki, Issei Seki, Reoto Kijima, Enkmurun Chibaatar, Atsuko Ikenouchi

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引用次数: 0

摘要

本研究探讨了血管内皮生长因子（VEGF）在18例首发精神分裂症（FES）患者和19例健康对照中的作用，以及利培酮单药治疗对血浆VEGF水平的影响。在基线和利培酮治疗四周后测量血浆VEGF水平。我们发现两组之间的基线VEGF水平没有差异，利培酮治疗后VEGF水平也没有变化。VEGF水平与症状严重程度之间没有相关性。我们的研究结果表明，VEGF可能不是FES的一个区别性生物标志物，也可能直接受到利培酮的影响。

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Effect of risperidone on plasma vascular endothelial growth factor levels in patients with first-episode schizophrenia: A preliminary study

This study investigated the role of vascular endothelial growth factor (VEGF) in 18 patients with first-episode schizophrenia (FES) and 19 healthy controls and the effect of risperidone monotherapy on plasma VEGF levels. The plasma VEGF levels were measured at baseline and after four weeks of risperidone treatment. We found no difference in baseline VEGF levels between the groups and no change in VEGF levels after risperidone treatment. No correlation was found between VEGF levels and symptom severity. Our findings suggest that VEGF may not serve as a distinguishing biomarker in FES or be directly influenced by risperidone.

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来源期刊

Psychiatry research communications Psychiatry and Mental Health

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

77 days